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Invitrogen
DNER Polyclonal Antibody
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DNER Antibody (PA5-47280) in IHC (F)
Immunohistochemical analysis of DNER in perfusion fixed frozen sections of mouse brain (cerebellum). Samples were incubated in DNER polyclonal antibody (Product # PA5-47280) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to Purkinje neurons and molecul... View More
产品信息
PA5-47280
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse DNER Ala26-His637
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human DNER is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain EGF repeat-containing transmembrane protein; Delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet
基因别名: A930026D19Rik; BET; Bret; Dner
UniProt ID: (Mouse) Q8JZM4
Entrez Gene ID: (Mouse) 227325
