Invitrogen

DYRK2/DYRK4 Polyclonal Antibody

Name: DYRK2\/DYRK4 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-106245
Availability: InStock

查看其他3个DYRK2/DYRK4抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

DYRK2/DYRK4 Antibody in Western Blot (WB)

图: 1 / 1

DYRK2/DYRK4 Antibody (PA5-106245) in WB

Western blot analysis of DYRK2/DYRK4 in HEK-293 cell lysate (left lane: treated with blocking peptide). Samples were incubated with DYRK2/DYRK4 polyclonal antibody (Product # PA5-106245).

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image DYRK2/DYRK4 Polyclonal Antibody

产品信息

PA5-106245

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human DYRK2(Accession Q92630), corresponding to amino acid residues G360-C410.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2817636

产品详细信息

Antibody detects endogenous levels of total DYRK2/4.

靶标信息

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4; Dual specificity tyrosine-phosphorylation-regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 4; Dyrk2; protein kinase; unnamed protein product

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基因别名: DYRK2; DYRK4

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Entrez Gene ID: (Human) 8445, (Human) 8798

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功能

magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding manganese ion binding protein serine kinase activity

参与通路

protein phosphorylation cellular response to DNA damage stimulus smoothened signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of glycogen biosynthetic process positive regulation of smoothened signaling pathway negative regulation of calcineurin-NFAT signaling cascade regulation of signal transduction by p53 class mediator