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Invitrogen
EDA2R Recombinant Rabbit Monoclonal Antibody (072)
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产品信息
MA5-30354
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
072
抗原
Recombinant Human XEDAR/EDA2R protein (Met1-Thr138)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human XEDAR/EDA2R.
靶标信息
X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappa-B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ectodysplasin A2 isoform receptor; EDA-A2 receptor; Tumor necrosis factor receptor superfamily member 27; tumor necrosis factor receptor superfamily member XEDAR; X-linked ectodysplasin-A2 receptor
基因别名: EDA-A2R; EDA2R; EDAA2R; TNFRSF27; UNQ2448/PRO5727/PRO34080; XEDAR
UniProt ID: (Human) Q9HAV5
Entrez Gene ID: (Human) 60401
multicellular organism development
epidermis development
tissue development
ectodermal cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JNK cascade
positive regulation of NF-kappaB transcription factor activity
intrinsic apoptotic signaling pathway by p53 class mediator
