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Invitrogen
IL-31 (Lokivetmab Biosimilar) Recombinant Canine Monoclonal Antibody
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IL-31 (Lokivetmab Biosimilar) Antibody (MA5-42047) in SDS-PAGE
SDS-PAGE analysis of the recombinant Canine (Canis lupus familiaris) IL31 protein expressed in CHO cells using a IL-31 (Lokivetmab Biosimilar) monoclonal antibody (Product # MA5-42047). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42047
产品规格
种属反应
Dog
宿主/亚型
Dog
/ IgG2, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Canine (Canis lupus familiaris) IL31
偶联物
形式
Liquid
浓度
2.4 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ILN; Interleukin
Entrez Gene ID: (Dog) 100302725
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