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Alomone Labs, LTD
KCNK16 (TALK-1) (extracellular) Polyclonal Antibody
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KCNK16 (TALK-1) (extracellular) Antibody (APC-170-200UL) in WB
Western blot analysisof human PANC-1 pancreas ductal adenocarcinoma cell line lysate: - 1. Anti-KCNK16 (TALK-1) (extracellular) Antibody (#APC-170), (1:600). 2. Anti-KCNK16 (TALK-1) (extracellular) Antibody , preincubated with KCNK16/TALK-1 (extracellular) Blocking Peptide (#BLP-PC170).
产品信息
APC-170-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EAWVKGVNPKGNST, corresponding to amino acid residues 75-88 of human KCNK16, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The KCNK16 gene encodes the TALK-1 channel, an abundant K+ channel transcript found in mouse and in human Beta-cells. There are four human TALK-1 transcript variants, including two that form functional K+ channels (TALK-1a (transcript variant 2) and TALK1-b (transcript variant 3). The TALK-1 structure includes 4 transmembrane domains, 2 extracellular loops, and intracellular N- and C-termini. The C-terminal tail of TALK-1 is a critical component that influences the magnitude of TALK-1 channel activation, while the N-terminus is important for protein interaction. TALK-1, two-pore domain K+ (K2p 16.1) channel is responsible for modulating glucose stimulated insulin secretion that relies on Beta-cell CA2+ influx. The channel produces outwardly rectifying, non-inactivating K+ currents, which are enhanced by elevations in extracellular pH. TALK-1 is thus pH-sensitive, with increased activity under alkaline conditions. In addition, it can be activated by singlet oxygen and nitric oxide.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2P domain potassium channel Talk-1; pancreatic potassium channel Talk-1; Potassium channel subfamily K member 16; Potassium channel, subfamily K, member 16; potassium channel, two pore domain subfamily K, member 16; TALK-1; TWIK-related alkaline pH-activated K(+) channel 1
基因别名: 4731413G05Rik; K2p16.1; KCNK16; TALK-1; TALK1
UniProt ID: (Human) Q96T55, (Mouse) G5E845
Entrez Gene ID: (Human) 83795, (Mouse) 74571, (Rat) 688996
