TALK-1 Antibodies

靶标信息

The KCNK16 gene encodes the TALK-1 channel, an abundant K+ channel transcript found in mouse and in human Beta-cells. There are four human TALK-1 transcript variants, including two that form functional K+ channels (TALK-1a (transcript variant 2) and TALK1-b (transcript variant 3). The TALK-1 structure includes 4 transmembrane domains, 2 extracellular loops, and intracellular N- and C-termini. The C-terminal tail of TALK-1 is a critical component that influences the magnitude of TALK-1 channel activation, while the N-terminus is important for protein interaction. TALK-1, two-pore domain K+ (K2p 16.1) channel is responsible for modulating glucose stimulated insulin secretion that relies on Beta-cell CA2+ influx. The channel produces outwardly rectifying, non-inactivating K+ currents, which are enhanced by elevations in extracellular pH. TALK-1 is thus pH-sensitive, with increased activity under alkaline conditions. In addition, it can be activated by singlet oxygen and nitric oxide.

同义词

2P domain potassium channel Talk-1; 4731413G05Rik; K2p16.1; KCNK16; pancreatic potassium channel Talk-1; potassium channel subfamily K member 16; potassium channel, subfamily K, member 16; potassium channel, two pore domain subfamily K, member 16; potassium two pore domain channel subfamily K member 16; TALK1; TALK-1; TWIK-related alkaline pH-activated K(+) channel 1