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Invitrogen
Actin Monoclonal Antibody (AC-40), Cyanine3
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Product Details
MA1-24907
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Fish,
Guinea pig,
Goat,
Hamster,
Human,
Mollusc,
Mouse,
Sheep,
Pig,
Rabbit,
Reptile,
Rat,
Xenopus
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
AC-40
Immunogen
Synthetic actin C-terminal peptide Ser-Gly-Pro-Ser-Ile-Val-His-Arg-Lys-Cys-Phe, attached to a Multiple Antigen Peptide (MAP) backbone.
Conjugate
Excitation/Emission Max
554/566 nm
View spectra
Form
Liquid
Concentration
1.1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: MDCK, human or chicken fibroblast.
Target Information
Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a-actin; ACTB; actin; actin alpha 1; actin alpha cardiac; actin alpha cardiac 1; actin homolog; actin, alpha 1, skeletal muscle; actin, alpha 2, smooth muscle, aorta; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; actin, alpha, cardiac 1; actin, alpha, cardiac muscle 1; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; actin, beta; actin, beta, cytoplasmic; Actin, cytoplasmic 1; Actin, cytoplasmic 2; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1; actin, gamma 1 propeptide; actin, gamma 2, smooth muscle, enteric; actin, gamma, cytoplasmic 1; Actin, gamma-enteric smooth muscle; actin-like protein; alpha 1 skeletal muscle actin; alpha actin; alpha actin 1; alpha actin 2; Alpha-actin; alpha-actin cardiac; Alpha-actin-1; Alpha-actin-2; Alpha-actin-3; Alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; alphac-actin; Atcb; B-actin; Bact; actin; beta actin; beta cytoskeletal actin; Beta-actin; beta-actin FE-3; cardiac actin; cardiac muscle alpha actin 1; Cell growth-inhibiting gene 46 protein; cytoplasmic 1; cytoplasmic 2; cytoplasmic actin; Cytoplasmic beta-actin; cytoplasmic type 5; cytoskeletal beta actin; cytoskeletal gamma-actin; cytoskeletal protein; deafness, autosomal dominant 20; deafness, autosomal dominant 26; epididymis luminal protein 176; gamma 1 propeptide; gamma non-muscle actin; Gamma-2-actin; Gamma-actin; gamma-enteric smooth muscle actin; nemaline myopathy type 3; pan actin; PS1TP5-binding protein 1; RP5-1068B5.2; skeletal alpha actin; smooth muscle alpha-actin; Smooth muscle gamma-actin; type 5; unnamed protein product; vascular smooth muscle alpha-actin
Gene Aliases: 0610041G09Rik; a-SMA; AA959943; AAT6; ACT; ACT-4; ACT-5; Act4; ACTA; Acta-2; ACTA1; ACTA2; ACTA3; ACTB; ACTC; Actc-1; ACTC1; ACTE; ACTG; ACTG1; ACTG2; ACTGE; actin; Actl; ACTL3; Acts; ACTSA; ACTSG; Actsk-1; ACTVS; Actx; AL023024; alphaSMA; ASD5; ASMA; Bact; Beta-actin; BRWS1; BRWS2; CFTD; CFTD1; CFTDM; CMD1R; CMH11; DFNA20; DFNA26; E430023M04Rik; E51; GAMMA-ACTIN; GIG46; HEL-176; I79_002310; I79_013242; I79_019066; LVNC4; MPFD; MYMY5; NEM1; NEM2; NEM3; PS1TP5BP1; SHPM; SMalphaA; SMGA; VSCM; XELAEV_18029136mg; XELAEV_18045052mg
UniProt ID: (Human) P68133, (Bovine) P68138, (Pig) P68137, (Bovine) P62739, (Human) P62736, (Rabbit) P62740, (Chicken) P08023, (Pig) Q6QAQ1, (Human) P60709, (Chicken) P60706, (Dog) O18840, (Rabbit) P29751, (Bovine) P60712, (Sheep) P60713, (Chicken) P04270, (Human) P68032, (Bovine) Q3ZC07, (Chicken) P53478, (Bovine) P63258, (Human) P63261, (Bovine) Q5E9B5, (Human) P63267, (Chicken) P63270, (Mouse) P68134, (Rat) P68136, (Mouse) P62737, (Rat) P62738, (Rat) P60711, (Guinea pig) Q71FK5, (Mouse) P60710, (Chinese hamster) P48975, (Rat) P68035, (Mouse) P68033, (Rat) P63259, (Mouse) P63260, (Mouse) P63268, (Rat) P63269, (Xenopus) O93400
Entrez Gene ID: (Rabbit) 100009506, (Sheep) 101107662, (Goat) 102182476, (Chicken) 421534, (Human) 58, (Bovine) 281592, (Pig) 100154254, (Dog) 488984, (Pig) 733615, (Goat) 102191486, (Bovine) 515610, (Human) 59, (Dog) 477587, (Rabbit) 100009271, (Chicken) 423787, (Sheep) 101121051, (Pig) 414396, (Human) 60, (Chicken) 396526, (Dog) 403580, (Rabbit) 100009272, (Bovine) 280979, (Sheep) 443052, (Goat) 102179831, (Dog) 478250, (Chicken) 423298, (Sheep) 101111554, (Pig) 100152267, (Human) 70, (Bovine) 533219, (Goat) 102170606, (Rabbit) 100340339, (Goat) 100860883, (Chicken) 415296, (Bovine) 404122, (Pig) 397653, (Sheep) 443340, (Human) 71, (Dog) 475923, (Goat) 102178279, (Bovine) 281595, (Human) 72, (Dog) 475792, (Sheep) 101114256, (Chicken) 396084, (Pig) 100520667, (Rabbit) 100350318, (Chinese hamster) 100768972, (Mouse) 11459, (Guinea pig) 100716933, (Rat) 29437, (Mouse) 11475, (Rat) 81633, (Chinese hamster) 100758575, (Guinea pig) 100722917, (Rat) 81822, (Guinea pig) 100135470, (Mouse) 11461, (Chinese hamster) 100689477, (Rat) 29275, (Guinea pig) 100731953, (Mouse) 11464, (Chinese hamster) 100766388, (Chinese hamster) 100764022, (Rat) 287876, (Mouse) 11465, (Guinea pig) 100731713, (Mouse) 11468, (Chinese hamster) 100768744, (Guinea pig) 100716255, (Rat) 25365, (Xenopus) 432314, (Xenopus) 398459
protein binding
ATP binding
structural constituent of cytoskeleton
myosin binding
ADP binding
protein kinase binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
kinesin binding
Tat protein binding
nucleosomal DNA binding
identical protein binding
nitric-oxide synthase binding
structural constituent of postsynaptic actin cytoskeleton
ATPase activity
profilin binding
ubiquitin protein ligase binding
nucleotide binding
molecular_function
actin and actin related protein
actin or actin-binding cytoskeletal protein
cytoskeletal protein
skeletal muscle thin filament assembly
skeletal muscle fiber development
muscle contraction
response to mechanical stimulus
response to extracellular stimulus
response to lithium ion
positive regulation of gene expression
cell growth
muscle filament sliding
skeletal muscle fiber adaptation
response to steroid hormone
mesenchyme migration
regulation of blood pressure
response to virus
vascular smooth muscle contraction
glomerular mesangial cell development
postsynaptic actin cytoskeleton organization
retina homeostasis
movement of cell or subcellular component
cytoskeleton organization
substantia nigra development
cell junction assembly
Fc-gamma receptor signaling pathway involved in phagocytosis
ATP-dependent chromatin remodeling
positive regulation of gene expression, epigenetic
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
platelet aggregation
axonogenesis
cell motility
morphogenesis of a polarized epithelium
establishment or maintenance of cell polarity
regulation of transmembrane transporter activity
negative regulation of protein binding
adherens junction assembly
apical protein localization
synaptic vesicle endocytosis
regulation of norepinephrine uptake
protein localization to adherens junction
cellular response to cytochalasin B
regulation of protein localization to plasma membrane
actin filament organization
actin-myosin filament sliding
heart contraction
apoptotic process
actin filament-based movement
actomyosin structure organization
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
cardiac muscle contraction
angiogenesis
positive regulation of cell migration
regulation of stress fiber assembly
regulation of focal adhesion assembly
positive regulation of wound healing
tight junction assembly
protein localization to bicellular tight junction
sarcomere organization
retina development in camera-type eye
cellular response to electrical stimulus
metabolic process
actin-mediated cell contraction
response to calcium ion
biological_process
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