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Invitrogen
Actin Monoclonal Antibody (AC-40), FITC
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Product Details
MA1-24908
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Fish,
Guinea pig,
Goat,
Hamster,
Human,
Mollusc,
Mouse,
Sheep,
Pig,
Rabbit,
Reptile,
Rat,
Xenopus
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
AC-40
Immunogen
Synthetic actin C-terminal peptide Ser-Gly-Pro-Ser-Ile-Val-His-Arg-Lys-Cys-Phe, attached to a Multiple Antigen Peptide (MAP) backbone.
Conjugate
FITC
FITC
FITC
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
2.9 mg/mL
Amount
145 µg
Purification
purified
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: MDCK, human or chicken fibroblast.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a-actin; ACT2; ACTB; actin; actin 2; actin 7; actin alpha 1; actin alpha cardiac; actin alpha cardiac 1; actin homolog; actin, alpha 1, skeletal muscle; actin, alpha 2, smooth muscle, aorta; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; actin, alpha, cardiac 1; actin, alpha, cardiac muscle 1; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; actin, beta, cytoplasmic; Actin, cytoplasmic 1; Actin, cytoplasmic 2; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1; actin, gamma 1 propeptide; actin, gamma 2, smooth muscle, enteric; actin, gamma, cytoplasmic 1; Actin, gamma-enteric smooth muscle; alpha 1 skeletal muscle actin; alpha actin; alpha actin 1; alpha actin 2; Alpha-actin; alpha-actin cardiac; Alpha-actin-1; Alpha-actin-2; Alpha-actin-3; Alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; alphac-actin; AtACT7; Atcb; B-actin; Bact; actin; beta actin; Beta-actin; beta-actin FE-3; cardiac actin; cardiac muscle alpha actin 1; Cell growth-inhibiting gene 46 protein; cytoplasmic 1; cytoplasmic 2; cytoplasmic actin; Cytoplasmic beta-actin; cytoplasmic type 5; cytoskeletal beta actin; cytoskeletal protein; DEFORMED ROOT HAIRS 1; DER1; ENHANCER OF LRX1 2; ENL2; FIZ2; FRIZZY AND KINKED SHOOTS 2; gamma 1 propeptide; gamma non-muscle actin; Gamma-2-actin; Gamma-actin; gamma-enteric smooth muscle actin; LIGHT STRESS-REGULATED 2; LSR2; MYH9.2; MYH9_2; pan actin; RP5-1068B5.2; skeletal alpha actin; smooth muscle alpha-actin; Smooth muscle gamma-actin; type 5; unnamed protein product; vascular smooth muscle alpha-actin
Gene Aliases: 0610041G09Rik; a-SMA; AA959943; ACT-4; ACT-5; Act4; ACTA; Acta-2; ACTA1; ACTA2; ACTA3; ACTB; ACTC; Actc-1; ACTC1; ACTG; ACTG1; ACTG2; ACTGE; actin; Actl; ACTL3; Acts; ACTSA; ACTSG; Actsk-1; ACTVS; Actx; AL023024; alphaSMA; asma; Bact; Beta-actin; cftd; cftd1; cftdm; E430023M04Rik; E51; GAMMA-ACTIN; GIG46; I79_002310; I79_013242; I79_019066; mpfd; nem1; SMalphaA; SMGA; XELAEV_18029136mg; XELAEV_18045052mg
UniProt ID: (Rabbit) P68135, (Chicken) P68139, (Bovine) P68138, (Pig) P68137, (Bovine) P62739, (Rabbit) P62740, (Chicken) P08023, (Pig) Q6QAQ1, (Chicken) P60706, (Dog) O18840, (Rabbit) P29751, (Bovine) P60712, (Sheep) P60713, (Chicken) P68034, (Bovine) Q3ZC07, (Chicken) P53478, (Bovine) P63258, (Bovine) Q5E9B5, (Chicken) P63270, (Mouse) P68134, (Rat) P68136, (Mouse) P62737, (Rat) P62738, (Rat) P60711, (Guinea pig) Q71FK5, (Mouse) P60710, (Chinese hamster) P48975, (Rat) P68035, (Mouse) P68033, (Rat) P63259, (Mouse) P63260, (Mouse) P63268, (Rat) P63269, (Xenopus) O93400
Entrez Gene ID: (Rabbit) 100009506, (Sheep) 101107662, (Goat) 102182476, (Chicken) 421534, (Bovine) 281592, (Pig) 100154254, (Dog) 488984, (Pig) 733615, (Goat) 102191486, (Bovine) 515610, (Dog) 477587, (Rabbit) 100009271, (Chicken) 423787, (Sheep) 101121051, (Pig) 414396, (Chicken) 396526, (Dog) 403580, (Rabbit) 100009272, (Bovine) 280979, (Sheep) 443052, (Goat) 102179831, (Dog) 478250, (Chicken) 423298, (Sheep) 101111554, (Pig) 100152267, (Bovine) 533219, (Goat) 102170606, (Rabbit) 100340339, (Goat) 100860883, (Chicken) 415296, (Bovine) 404122, (Pig) 397653, (Sheep) 443340, (Dog) 475923, (Goat) 102178279, (Bovine) 281595, (Dog) 475792, (Sheep) 101114256, (Chicken) 396084, (Pig) 100520667, (Rabbit) 100350318, (Chinese hamster) 100768972, (Mouse) 11459, (Guinea pig) 100716933, (Rat) 29437, (Mouse) 11475, (Rat) 81633, (Chinese hamster) 100758575, (Guinea pig) 100722917, (Rat) 81822, (Guinea pig) 100135470, (Mouse) 11461, (Chinese hamster) 100689477, (Rat) 29275, (Guinea pig) 100731953, (Mouse) 11464, (Chinese hamster) 100766388, (Chinese hamster) 100764022, (Rat) 287876, (Mouse) 11465, (Guinea pig) 100731713, (Mouse) 11468, (Chinese hamster) 100768744, (Guinea pig) 100716255, (Rat) 25365, (Xenopus) 432314, (Xenopus) 398459
protein binding
ATP binding
protein kinase binding
structural constituent of postsynaptic actin cytoskeleton
kinesin binding
Tat protein binding
identical protein binding
nitric-oxide synthase binding
myosin binding
profilin binding
ubiquitin protein ligase binding
nucleotide binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
nucleosomal DNA binding
ATPase activity
molecular_function
structural constituent of cytoskeleton
actin and actin related protein
actin or actin-binding cytoskeletal protein
cytoskeletal protein
skeletal muscle thin filament assembly
skeletal muscle fiber development
positive regulation of gene expression
mesenchyme migration
regulation of blood pressure
response to virus
vascular smooth muscle contraction
glomerular mesangial cell development
postsynaptic actin cytoskeleton organization
axonogenesis
cell motility
morphogenesis of a polarized epithelium
establishment or maintenance of cell polarity
regulation of transmembrane transporter activity
negative regulation of protein binding
adherens junction assembly
apical protein localization
synaptic vesicle endocytosis
regulation of norepinephrine uptake
protein localization to adherens junction
cellular response to cytochalasin B
regulation of protein localization to plasma membrane
actin filament organization
actin-myosin filament sliding
heart contraction
angiogenesis
positive regulation of cell migration
regulation of stress fiber assembly
regulation of focal adhesion assembly
positive regulation of wound healing
tight junction assembly
protein localization to bicellular tight junction
response to mechanical stimulus
response to extracellular stimulus
response to lithium ion
cell growth
skeletal muscle fiber adaptation
response to steroid hormone
muscle contraction
retina homeostasis
substantia nigra development
ATP-dependent chromatin remodeling
retina development in camera-type eye
platelet aggregation
cellular response to electrical stimulus
metabolic process
actin filament-based movement
actomyosin structure organization
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
cardiac muscle contraction
actin-mediated cell contraction
sarcomere organization
response to calcium ion
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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