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THRA/THRB Monoclonal Antibody (H43), APC

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THRA/THRB Monoclonal Antibody (H43), APC

产品信息

MA5-45921

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化 (IHC)

1:100
-

免疫细胞化学 (ICC/IF)

1:250
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

H43

抗原

Synthetic peptide from the full length Human Thyroid hormone receptor protein
查看免疫原

偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱 spectra

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA

内含物

no preservative

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2932375

产品详细信息

A 1:500 dilution of MA5-45921 was sufficient for detection of Pan-Thyroid hormone receptor in 10 µg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Detects 70 kDa.

靶标信息

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA protooncogene; c-erbA-1; c-erbA-2; C-erbA-alpha; c-erbA-alpha2; c-erbA-beta; c-erbAalpha; c-erbAalpha2; EAR-7; ERBA-related 7; nuclear receptor; Nuclear receptor subfamily 1 group A member 1; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; THR; THRA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR alpha 1; TR alpha 2; TR beta; TRbeta2Delta; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7

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基因别名: 6430529J03Rik; AR7; AW259572; c-erbA; c-ERBA-1; C-ERBA-2; C-erba-alpha; C-ERBA-BETA; c-erbAbeta; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; ERBA2; GRTH; NR1A1; NR1A2; PRTH; RATT3REC; Rvr; T3R[a]; T3R[b]; T3Ralpha; T3Rbeta; T3rec; THR1; THRA; THRA1; THRA2; THRalpha; THRalpha1; THRalpha2; THRB; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2; TRalpha; TRalpha1; TRalpha2; TRb; TRbeta; TRbeta1

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UniProt ID: (Human) P10827, (Human) P10828, (Mouse) P63058, (Rat) P63059, (Mouse) P37242

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Entrez Gene ID: (Human) 7067, (Human) 7068, (Mouse) 21833, (Rat) 81812, (Mouse) 21834, (Rat) 24831

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功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding TBP-class protein binding protein domain specific binding chromatin DNA binding sequence-specific DNA binding macromolecular complex binding metal ion binding thyroid hormone binding general transcription initiation factor binding transcription coactivator binding chromatin binding enzyme binding sequence-specific double-stranded DNA binding steroid receptor RNA activator RNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity single-stranded RNA binding thyroid hormone receptor activity transcription factor binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity protein dimerization activity double-stranded DNA binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
参与通路
negative regulation of transcription from RNA polymerase II promoter cartilage condensation ossification thyroid hormone mediated signaling pathway regulation of thyroid hormone mediated signaling pathway positive regulation of thyroid hormone receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter learning or memory regulation of heart contraction female courtship behavior response to cold hormone-mediated signaling pathway organ morphogenesis negative regulation of RNA polymerase II transcriptional preinitiation complex assembly cell differentiation erythrocyte differentiation thyroid gland development regulation of myeloid cell apoptotic process mRNA transcription from RNA polymerase II promoter negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway regulation of lipid catabolic process Type I pneumocyte differentiation positive regulation of cold-induced thermogenesis negative regulation of DNA-templated transcription, initiation transcription, DNA-templated sensory perception of sound negative regulation of female receptivity retinal cone cell development cellular response to thyroid hormone stimulus retinal cone cell apoptotic process positive regulation of myotube differentiation intracellular receptor signaling pathway cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity kidney development liver development brain development lung development adrenal gland development response to nutrient levels response to drug digestive tract development embryonic organ development positive regulation of cell proliferation regulation of lipid metabolic process positive regulation of chondrocyte differentiation positive regulation of ossification regulation of cholesterol metabolic process regulation of triglyceride metabolic process
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