Invitrogen

THRA/THRB Monoclonal Antibody (H43), PerCP

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THRA/THRB Monoclonal Antibody (H43), PerCP

Product Details

MA5-45923

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (IHC)

1:100
-

Immunocytochemistry (ICC/IF)

1:250
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

H43

Immunogen

Synthetic peptide from the full length Human Thyroid hormone receptor protein
View immunogen

Conjugate

PerCP PerCP PerCP

Excitation/Emission Max

482/675 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932377

Product Specific Information

A 1:500 dilution of MA5-45923 was sufficient for detection of Pan-Thyroid hormone receptor in 10 µg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Detects 70 kDa.

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA-1; c-erbA-2; C-erbA-alpha; c-erbA-alpha2; c-erbA-beta; c-erbAalpha; c-erbAalpha2; EAR-7; ERBA-related 7; Nuclear receptor subfamily 1 group A member 1; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; THR; thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 2; TR beta; TRbeta2Delta; triiodothyronine receptor; V-erbA-related protein 7

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Gene Aliases: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-ERBA-2; C-erba-alpha; C-ERBA-BETA; c-erbAbeta; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; ERBA2; GRTH; NR1A1; NR1A2; PRTH; RATT3REC; Rvr; T3R[a]; T3R[b]; T3Ralpha; T3Rbeta; T3rec; THR1; THRA; THRA1; THRA2; THRB; THRB1; THRB2; TRbeta

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UniProt ID: (Human) P10827, (Human) P10828, (Mouse) P63058, (Rat) P63059, (Mouse) P37242

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Entrez Gene ID: (Human) 7067, (Human) 7068, (Mouse) 21833, (Rat) 81812, (Mouse) 21834, (Rat) 24831

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Function(s)
transcription regulatory region sequence-specific DNA binding steroid receptor RNA activator RNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity thyroid hormone receptor activity protein binding transcription factor binding zinc ion binding TBP-class protein binding protein domain specific binding chromatin DNA binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity thyroid hormone binding DNA binding transcription corepressor activity enzyme binding sequence-specific DNA binding single-stranded RNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding metal ion binding protein dimerization activity double-stranded DNA binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
cartilage condensation ossification kidney development liver development regulation of thyroid hormone mediated signaling pathway regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter brain development learning or memory regulation of heart contraction female courtship behavior response to cold hormone-mediated signaling pathway positive regulation of myotube differentiation negative regulation of RNA polymerase II transcriptional preinitiation complex assembly erythrocyte differentiation adrenal gland development intracellular receptor signaling pathway thyroid gland development response to nutrient levels regulation of myeloid cell apoptotic process response to drug cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter digestive tract development embryonic organ development regulation of lipid catabolic process Type I pneumocyte differentiation negative regulation of DNA-templated transcription, initiation negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated sensory perception of sound negative regulation of female receptivity organ morphogenesis regulation of transcription, DNA-templated lung development positive regulation of cell proliferation regulation of lipid metabolic process positive regulation of chondrocyte differentiation positive regulation of ossification regulation of cholesterol metabolic process regulation of triglyceride metabolic process
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