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Alomone Labs, LTD
MC4 Receptor (extracellular) Polyclonal Antibody
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MC4 Receptor (extracellular) Antibody (AMR-024-200UL) in ICC/IF
Expression of MC4R inrat pituitary cell line - Cell surface detection of MC4R in live intact GH3 cells with Anti-MC4 Receptor (extracellular) Antibody (#AMR-024), (1:50). A. MC4R staining was observed,followed by Alexa-555-conjugated goat Anti-rabbit secondary Antibody (red).Hoechst 33342 (blue) is used to visualize the nuclei. B. Live view of the same field as A.
产品信息
AMR-024-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HRGMHTSLHLWNRSS, corresponding to amino acid residues 6-20 of human MC4R, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MC4; MC4 receptor; MC4-R; Melanocortin receptor 4
基因别名: Mc4-r; MC4R
UniProt ID: (Human) P32245, (Rat) P70596, (Mouse) P56450
Entrez Gene ID: (Human) 4160, (Rat) 25635, (Mouse) 17202
diet induced thermogenesis
energy reserve metabolic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
feeding behavior
insulin secretion
positive regulation of cAMP biosynthetic process
response to insulin
positive regulation of bone resorption
negative regulation of feeding behavior
regulation of grooming behavior
G-protein coupled receptor signaling pathway
regulation of metabolic process
regulation of feeding behavior
signal transduction
