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Invitrogen
MTGR1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96556
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 of human CBFA2T2 (NP_0050841)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.58 mg/mL
Amount
58 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GLNGGYQDEL VDHRLTEREW ADEWKHLDHA LNCIMEMVEK TRRSMAVLRR CQESDREELN YWKRRYNENT ELRKTGTELV SRQHSPGSAD SLSNDSQREF NSRPGTGYVP VEFWKKTEEA VNKVKIQAMS EVQKAVAEAE QKAFEVIATE RARMEQTIAD VKRQAAEDAF LVINEQEEST ENCWNCGRKA SETCSGCNIA RYCGSFCQHK DWERHHRLCG QNLHGQSPHG QGRPLLPVGR GSSARSADCS VPSPALDKTS ATTSRSSTPA SVTAIDTNGL; Positive Samples: Jurkat, Raji, HepG2, SW620, 22Rv1, Mouse brain, Mouse testis, Mouse kidney, Rat brain; Cellular Location: Nucleus
Target Information
Myeloid tumor related gene (MTGR1) is found deleted in acute myeloid leukemia. Overexpression of MTGR1 can stimulate AML1-MTG8 to induce GCSF- dependent proliferation of L-G cells and to interfere with AML1- dependent transcription. AML1/MTG8 functions as a complex with MTGR1 and that the complex might be important in promoting leukemogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CBFA2T2 identified gene homolog; core-binding factor runt domain alpha subunit 2 translocated to 2 homolog; core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog; DKFZp313F2116; MTG8-like protein; MTG8-related protein 1; Protein CBFA2T2; RP5-1137F22.1; translocated to, 2; ZMYND3 CBFA2T2
Gene Aliases: A430091M07; C330013D05Rik; Cbfa2t2; Cbfa2t2h; MTGR1
UniProt ID: (Mouse) O70374
Entrez Gene ID: (Rat) 296293, (Mouse) 12396
positive regulation of neuron projection development
epithelial cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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