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Invitrogen

NOR-1 Polyclonal Antibody

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NOR-1 Polyclonal Antibody

Product Details

PA5-115669

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NR4A3(Accession Q92570), corresponding to amino acid residues S390-L440.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900304

Product Specific Information

Antibody detects endogenous levels of total NR4A3.

Target Information

NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; mitogen-induced nuclear orphan receptor; neural orphan receptor 1; neuron-derived orphan receptor 1; neuron-derived orphan receptor 1/2; Nor1; nuclear hormone receptor NOR-1; nuclear hormone receptor NOR-1/NOR-2; orphan nuclear receptor TEC; steroid/thyroid orphan receptor homolog gene; TEC receptor; translocated in extraskeletal chondrosarcoma

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Gene Aliases: CHN; CSMF; MINOR; NOR-1; NOR-2; NOR1; TEC

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UniProt ID: (Human) Q92570, (Rat) P51179, (Mouse) Q9QZB6

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Entrez Gene ID: (Human) 8013, (Rat) 58853, (Mouse) 18124

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding protein kinase binding histone acetyltransferase binding glucocorticoid receptor binding cAMP response element binding protein homodimerization activity sequence-specific DNA binding double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter mesoderm formation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter gastrulation axon guidance positive regulation of cardiac muscle hypertrophy positive regulation of glucose transport hippocampus development intracellular receptor signaling pathway adult behavior organ regeneration positive regulation of mast cell cytokine production intracellular signal transduction common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway inner ear morphogenesis response to hydrogen peroxide negative regulation of apoptotic process mast cell degranulation response to peptide hormone negative regulation of neuron apoptotic process cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter platelet-derived growth factor receptor signaling pathway regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation negative regulation of inflammatory response neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of leukocyte apoptotic process positive regulation of feeding behavior regulation of apoptotic process intracellular steroid hormone receptor signaling pathway
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