Antibodies Inc

Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31), FL650

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问题与答案

问题与答案

Immunogen image

Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31), FL650

Immunogen Image Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31), FL650

产品信息

75-226-FL650

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

N126B/31

抗原

Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli.

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偶联物

FL650 FL650 FL650

激发/发射光谱

655/676 nm

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

Neuregulin-CRD refers to the cysteine-rich domain (CRD) of neuregulins, a family of signaling proteins involved in various cellular processes, including growth, differentiation, and development. The cysteine-rich domain is critical for the interaction of neuregulins with their receptors, such as the ErbB family of receptor tyrosine kinases, facilitating the activation of downstream signaling pathways. This domain plays a vital role in the proper functioning of neuregulins in the nervous system, heart, and other tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor

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基因别名: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297

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Entrez Gene ID: (Human) 3084, (Rat) 112400

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transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding protein tyrosine kinase activator activity growth factor

MAPK cascade activation of MAPK activity cell morphogenesis startle response cardiac conduction system development ventricular trabecula myocardium morphogenesis cell communication activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development locomotory behavior regulation of blood pressure positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling glucose transport peptidyl-tyrosine phosphorylation glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein homodimerization activity regulation of protein heterodimerization activity positive regulation of GTPase activity neurotransmitter receptor metabolic process positive regulation of axon extension negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling neuron fate commitment oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of secretion positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration transmembrane receptor protein tyrosine kinase signaling pathway heart development muscle organ development cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process cell migration cell differentiation positive regulation of cell growth cellular protein complex disassembly regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity animal organ development ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation positive regulation of protein tyrosine kinase activity negative regulation of extrinsic apoptotic signaling pathway in absence of ligand