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Antibodies Inc
Pan-PTPR (Receptor-Type Tyrosine-Protein Phosphatase) Monoclonal Antibody (N165/43), FL650
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产品信息
75-194-FL650
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N165/43
抗原
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (accession number P10586) produced recombinantly in E. Coli.
偶联物
激发/发射光谱
655/676 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
Pan-PTPR refers to the collective group of Protein Tyrosine Phosphatase Receptor (PTPR) family members, which are enzymes that dephosphorylate tyrosine residues on proteins. These receptors play key roles in regulating a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Their dysregulation is often associated with various diseases, including cancer and autoimmune disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LAR; LAR-PTP2; LCA-homolog; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; Leukocyte common antigen related; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase receptor-type F; protein tyrosine phosphatase, receptor type, D; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase, receptor type, F polypeptide; protein tyrosine phosphatase, receptor type, S; Protein-tyrosine phosphatase delta; PTPNU-3; R-PTP-delta; R-PTP-S; R-PTP-sigma; receptor-linked protein-tyrosine phosphatase LAR; Receptor-type tyrosine-protein phosphatase delta; Receptor-type tyrosine-protein phosphatase F; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; tissue-specific protein tyrosine phosphatase
基因别名: 1110002J03Rik; 3000002J10Rik; AA591035; AL022616; B230219D21Rik; BNAH2; HPTP; HPTPD; HPTPDELTA; LAR; LARFN5C; Larptp2; LARS; PTP; PTP-NU3; PTPD; PTPNU-3; PTPRD; PTPRF; PTPRS; PTPSIGMA; Ptpsigma.; Ptpt9; R-PTP-delta; R-PTP-S; R-PTP-sigma; RPTP-LAR; Rptpd; RPTPDELTA; RPTPsigma
UniProt ID: (Human) P23468, (Human) P10586, (Human) Q13332, (Mouse) Q64487, (Rat) Q64604, (Mouse) A2A8L5, (Mouse) B0V2N1, (Rat) Q64605
Entrez Gene ID: (Human) 5789, (Human) 5792, (Human) 5802, (Mouse) 19266, (Rat) 313278, (Rat) 360406, (Mouse) 19268, (Mouse) 19280, (Rat) 25529
transmembrane receptor protein tyrosine phosphatase activity
receptor binding
protein binding
cell adhesion molecule binding
protein tyrosine phosphatase activity
heparin binding
protein complex binding
chondroitin sulfate proteoglycan binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
insulin receptor binding
receptor tyrosine kinase binding
phosphate ion binding
protein phosphatase
protein modifying enzyme
protein dephosphorylation
phosphate-containing compound metabolic process
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
transmembrane receptor protein tyrosine phosphatase signaling pathway
chemical synaptic transmission
neuron differentiation
peptidyl-tyrosine dephosphorylation
positive regulation of dendrite morphogenesis
presynaptic membrane assembly
cell adhesion
cell migration
neuron projection regeneration
regulation of axon regeneration
negative regulation of receptor binding
spinal cord development
cerebellum development
hippocampus development
cerebral cortex development
corpus callosum development
establishment of endothelial intestinal barrier
dephosphorylation
negative regulation of JAK-STAT cascade
regulation of immune response
negative regulation of cytokine-mediated signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
nervous system development
negative regulation of cell proliferation
regulation of neuron projection development
negative regulation of cell projection organization
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of insulin receptor signaling pathway
regulation of synapse structure or activity
negative regulation of neurotrophin TRK receptor signaling pathway
signal transduction
