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Invitrogen
Phospho-ANKRD28 (Ser1007) Polyclonal Antibody
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Phospho-ANKRD28 (Ser1007) Antibody (PA5-105964) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-ANKRD28 (Ser1040) in human gastric cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-ANKRD28 (Ser1040) polyclonal antibody (Product # PA5-105964) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105964
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ANKRD28(Accession O15084), corresponding to amino acid residues around phosphorylated Ser1007.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of ANKRD28 only when phosphorylated at Ser1007.
靶标信息
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat domain-containing protein 28; phosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; PITK; PP6-ARS-A; protein phosphatase 1, regulatory subunit 65; protein phosphatase 6 ankyrin repeat subunit A; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
基因别名: AI465466; AI604979; ANKRD28; E430019N21Rik; KIAA0379; mKIAA0379; PITK; PPP1R65
UniProt ID: (Human) O15084, (Mouse) Q505D1
Entrez Gene ID: (Human) 23243, (Mouse) 105522
