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Antibodies Inc
QKI-5 Monoclonal Antibody (N195A/16)
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QKI-5 Antibody (75-232) in WB
Western blot of protein extracted from UD hESCs, DE cells, and CM cells probed with antibodies for QKI5 (magenta, top panel) and panQKI (green), QKI6 (magenta, middle panel) and panQKI (green), or QKI7 (magenta, bottom panel; ND denotes not detectable) and panQKI (green). Image from publication CC-BY-4.0. PMID: 35544276.
产品信息
75-232
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N195A/16
抗原
Synthetic peptide amino acids 315-331 of human QKI-5 (accession number Q96PU).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: ATKVRRHDMR VHPYQRI
靶标信息
The QKI gene, also known as Quaking, encodes an RNA-binding protein that plays a critical role in myelination, as it is predominantly expressed in oligodendrocytes and Schwann cells. The QKI protein is involved in the regulation of mRNA stability, splicing, and export, which influences the development and differentiation of the nervous system. The QKI gene produces several isoforms, including QKI-5, QKI-6, and QKI-7, each having distinct functions and expression patterns. QKI-5, one of the major isoforms, is primarily located in the nucleus where it regulates RNA processing events essential for cell development and function. Mutations or dysregulation of the QKI gene have been implicated in various neurological disorders, including schizophrenia and myelin-related diseases such as multiple sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; KH domain-containing RNA-binding protein QKI; lethal, Chr 17, U Wisconsin 1; MqkI; Protein quaking; protein quaking-like; QKI, KH domain containing, RNA binding; QKI-5 protein; quaking homolog, KH domain RNA binding; RNA binding protein HQK
基因别名: 1110003F05Rik; 1500005P18; HKQ; Hqk; hqkI; l(17)-1Wis; l17Wis1; QK; QK1; QK3; QKI
UniProt ID: (Human) Q96PU8, (Mouse) Q9QYS9
Entrez Gene ID: (Human) 9444, (Mouse) 19317, (Rat) 100910212
vasculogenesis
mRNA processing
spermatid development
RNA splicing
positive regulation of gene expression
myelination
muscle cell differentiation
long-chain fatty acid biosynthetic process
mRNA transport
3'-UTR-mediated mRNA destabilization
regulation of translation
transport
multicellular organism development
axon ensheathment
cell differentiation
