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Invitrogen
RAGE Polyclonal Antibody
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RAGE Antibody (PA5-48057) in WB
Western blot was performed using Anti-RAGE Polyclonal Antibody (Product # PA5-48057) and 45, 55 kDa bands corresponding to RAGE was observed in Mouse Lung, Rat Lung but not in Mouse Heart, Mouse Skeletal Muscle which are reported to be negative. Tissue extracts (30 µg lysate) of Mouse Lung (Lane 1), Rat Lung (Lane 2), Mouse Heart (Lane 3) and Mouse Skeletal Muscle (Lane 4) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB... View More
产品信息
PA5-48057
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog
已发表种属
Rat
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant canine RAGE Asp25-Val339
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In sandwich ELISAs, approximately 0.5% cross-reactivity with recombinant human RAGE is observed and less than 0.1% cross-reactivity with recombinant mouse RAGE and recombinant rat RAGE is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-β peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-?B activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: advanced glycation end product receptor; advanced glycation end-product receptor; RAGE-4 ORF3; RAGE/AGER; receptor for advanced glycation endproducts; receptor of advanced glycosylation end products of proteins; immunoglobulin superfamily; MHC class II; MHC class III; sRAGE
基因别名: RAGE
Entrez Gene ID: (Dog) 403168
