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          • Primary Antibodies ›
          • RAGE Antibodies

          Invitrogen

          RAGE Recombinant Rabbit Monoclonal Antibody (5M7T7)

          查看其他27个RAGE抗体

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          Cite RAGE Recombinant Rabbit Monoclonal Antibody (5M7T7)

          Additional Information:
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          • 抗体检测数据 (6)
          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 6

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          RAGE Antibody (MA569096) in IHC (P)

          Immunohistochemistry analysis of RAGE on paraffin-embedded Human lung tissue. Samples were incubated with RAGE recombinant monoclonal antibody (Product # MA569096) using a dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) using a dilution of 1:500. DAPI for nuclear staining (Blue). High pressure antigen retrieval performed with 0. 01 M Citrate Buffer (pH 6. 0). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          RAGE Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          RAGE Antibody in Western Blot (WB)

          产品信息

          MA569096

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000-1:5,000
          -

          免疫组化(石蜡) (IHC (P))

          1:5,000-1:20,000
          -

          免疫细胞化学 (ICC/IF)

          1:100-1:2400
          -

          酶联免疫吸附实验 (ELISA)

          1 µg/mL
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          Expression System

          HEK293 cells

          分类

          Recombinant Monoclonal

          类型

          Antibody

          克隆号

          5M7T7

          抗原

          Recombinant protein (or fragment).

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.92 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.3., with 50% glycerol

          内含物

          0.09% sodium azide

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          靶标信息

          The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-beta peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-kB activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: advanced glycation end-products receptor; advanced glycosylation end product receptor; Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE-4 ORF3; RAGEdelex2-6; RAGEdelex3; RAGEdelex3-10; RAGEdelex3-7; RAGEdelex8&int9; RAGEint4; RAGEint4&9; RAGEint9&delex11; RAGEv1; RAGEv8; receptor for advanced glycation end-products; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; soluble receptor; sRAGE; unnamed protein product

          查看更多 收起

          基因别名: AGER; RAGE; SCARJ1; sRAGE

          查看更多 收起

          UniProt ID: (Human) Q15109, (Mouse) Q62151

          查看更多 收起

          Entrez Gene ID: (Human) 177, (Rat) 81722, (Mouse) 11596

          查看更多 收起

          功能
          beta-amyloid binding DNA binding RNA binding transmembrane signaling receptor activity scavenger receptor activity laminin receptor activity protein binding signaling receptor activity histone binding identical protein binding S100 protein binding macromolecular complex binding advanced glycation end-product receptor activity binding, bridging high mobility group box 1 binding cell adhesion molecule immunoglobulin superfamily cell adhesion molecule
          参与通路
          response to hypoxia microglial cell activation positive regulation of cytokine production regulation of T cell mediated cytotoxicity DNA replication DNA repair phagocytosis inflammatory response cellular response to DNA damage stimulus cell adhesion cell surface receptor signaling pathway learning or memory positive regulation of cell proliferation response to wounding negative regulation of biosynthetic process glucose mediated signaling pathway astrocyte development regulation of cell adhesion positive regulation of cell migration neuron projection development negative regulation of interleukin-10 production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of heterotypic cell-cell adhesion positive regulation of activated T cell proliferation transcytosis positive regulation of cell differentiation positive regulation of JNK cascade astrocyte activation regulation of synaptic plasticity regulation of inflammatory response induction of positive chemotaxis positive regulation of DNA metabolic process positive regulation of NF-kappaB transcription factor activity negative regulation of multicellular organismal process positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus positive regulation of monocyte chemotactic protein-1 production protein localization to membrane regulation of spontaneous synaptic transmission transport across blood-brain barrier regulation of long-term synaptic potentiation negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression regulation of p38MAPK cascade positive regulation of p38MAPK cascade regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of amyloid precursor protein catabolic process negative regulation of blood circulation positive regulation of endothelin production negative regulation of connective tissue replacement involved in inflammatory response wound healing response to amyloid-beta cellular response to beta-amyloid positive regulation of DNA-dependent DNA replication positive regulation of monocyte extravasation regulation of CD4-positive, alpha-beta T cell activation positive regulation of double-strand break repair positive regulation of dendritic cell differentiation negative regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation negative regulation of cell adhesion JAK-STAT cascade brain development glycoprotein metabolic process response to fructose positive regulation of autophagy negative regulation of endothelial cell migration positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration response to activity positive regulation of smooth muscle cell migration lung development negative regulation of collagen biosynthetic process response to vitamin A response to genistein negative regulation of osteoblast proliferation cellular response to drug positive regulation of apoptotic process positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of DNA binding response to methylglyoxal calcium ion homeostasis response to hyperoxia positive regulation of phagocytosis, engulfment transdifferentiation cellular response to hydrogen peroxide cellular response to fatty acid cellular response to organic cyclic compound response to selenite ion positive regulation of potassium ion transmembrane transporter activity positive regulation of neuron death positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process positive regulation of type B pancreatic cell apoptotic process
          It has to be done as per old AB suggested Products section.

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