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Invitrogen
RFC5 Polyclonal Antibody
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RFC5 Antibody (PA5-103494) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded RFC5 in human lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with RFC5 polyclonal antibody (Product # PA5-103494) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-103494
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RFC5(Accession P40937), corresponding to amino acid residues L71-L121.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total RFC5.
靶标信息
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A1 36 kDa subunit; Activator 1 36 kDa subunit; Activator 1 subunit 5; MGC1155; replication factor C (activator 1) 5, 36.5kDa; Replication factor C 36 kDa subunit; replication factor C 5; Replication factor C subunit 5; replication factor C, 36 kDa; replication factor C, 36-kDa subunit; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; RFC36
基因别名: 2610020K06Rik; 2610209F07Rik; 36.5kDa; 36kDa; Recc5; RFC36; RFC5
UniProt ID: (Human) P40937, (Mouse) Q9D0F6
Entrez Gene ID: (Human) 5985, (Mouse) 72151
telomere maintenance via recombination
DNA replication
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA gap filling
translesion synthesis
nucleotide-excision repair, DNA incision
error-prone translesion synthesis
DNA damage response, detection of DNA damage
error-free translesion synthesis
positive regulation of DNA-directed DNA polymerase activity
regulation of signal transduction by p53 class mediator
DNA-dependent DNA replication
