Abnova

SIRT6 Monoclonal Antibody (1D8)

查看其他24个SIRT6抗体

问题与答案

问题与答案

问题与答案

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抗体检测数据 (1)

SIRT6 Antibody in ELISA (ELISA)

SIRT6 Antibody in ELISA (ELISA)

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SIRT6 Antibody (H00051548-M01) in ELISA

Detection limit for recombinant GST tagged SIRT6 is 1 ng/mL as a capture antibody.

SIRT6 Antibody in ELISA (ELISA)

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

SIRT6 Antibody in ELISA (ELISA) — Detection limit for recombinant GST tagged SIRT6 is 1 ng/mL as a capture antibody.

Immunogen image

SIRT6 Monoclonal Antibody (1D8)

Immunogen Image SIRT6 Monoclonal Antibody (1D8)

产品信息

H00051548-M01

应用

建议稀释比

已发表文章

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

1D8

抗原

SIRT6 (NP_057623.1, 141 a.a. approximately 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Sandwich ELISA (Recombinant protein).

Immunogen sequence: CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA

靶标信息

Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human aging.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: NAD-dependent protein deacetylase sirtuin-6; protein mono-ADP-ribosyltransferase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2; SIR2 like 6; SIR2-like protein 6; sir2-related protein type 6; SIRT6; sirtuin type 6; sirtuin6; unnamed protein product

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基因别名: hSIRT6; SIR2L6

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UniProt ID: (Human) Q8N6T7

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Entrez Gene ID: (Human) 51548

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DNA binding chromatin binding damaged DNA binding transcription corepressor activity NAD+ ADP-ribosyltransferase activity protein binding zinc ion binding NAD-dependent histone deacetylase activity chromatin DNA binding nucleosome binding histone deacetylase activity (H3-K9 specific) NAD-dependent protein deacetylase activity protein homodimerization activity NAD-dependent histone deacetylase activity (H3-K9 specific) NAD+ binding NAD-dependent histone deacetylase activity (H3-K18 specific) NAD+-protein-arginine ADP-ribosyltransferase activity DNA damage sensor activity histone H3K56 deacetylase activity, NAD-dependent NAD-dependent protein demyristoylase activity NAD-dependent protein depalmitoylase activity NAD+-protein-lysine ADP-ribosyltransferase activity TORC2 complex binding protein ADP-ribosylase activity

negative regulation of transcription from RNA polymerase II promoter regulation of gluconeogenesis regulation of DNA repair base-excision repair double-strand break repair chromatin remodeling protein deacetylation protein import into nucleus negative regulation of cell proliferation determination of adult lifespan response to UV negative regulation of transposition, RNA-mediated regulation of double-strand break repair via homologous recombination regulation of lipid metabolic process pericentric heterochromatin assembly telomeric heterochromatin assembly protein destabilization positive regulation of insulin secretion positive regulation of telomere maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process circadian regulation of gene expression negative regulation of transcription elongation from RNA polymerase II promoter ketone biosynthetic process negative regulation of protein import into nucleus glucose homeostasis regulation of circadian rhythm post-translational protein modification positive regulation of fat cell differentiation negative regulation of gluconeogenesis negative regulation of gene expression, epigenetic negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of glucose import positive regulation of protein export from nucleus positive regulation of fibroblast proliferation regulation of protein secretion regulation of lipid catabolic process protein delipidation cardiac muscle cell differentiation positive regulation of cold-induced thermogenesis negative regulation of protein localization to chromatin positive regulation of protein localization to chromatin DNA repair-dependent chromatin remodeling positive regulation of stem cell population maintenance positive regulation of chondrocyte proliferation regulation of protein localization to plasma membrane positive regulation of blood vessel branching positive regulation of vascular endothelial cell proliferation protein localization to site of double-strand break positive regulation of stem cell proliferation positive regulation of stem cell differentiation negative regulation of cellular senescence positive regulation of double-strand break repair