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Invitrogen
TALK-1 Polyclonal Antibody
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产品信息
PA5-144235
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Potassium channel subfamily K member 16 protein (259-309AA)
偶联物
形式
Liquid
浓度
3.5 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% Proclin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The KCNK16 gene encodes the TALK-1 channel, an abundant K+ channel transcript found in mouse and in human Beta-cells. There are four human TALK-1 transcript variants, including two that form functional K+ channels (TALK-1a (transcript variant 2) and TALK1-b (transcript variant 3). The TALK-1 structure includes 4 transmembrane domains, 2 extracellular loops, and intracellular N- and C-termini. The C-terminal tail of TALK-1 is a critical component that influences the magnitude of TALK-1 channel activation, while the N-terminus is important for protein interaction. TALK-1, two-pore domain K+ (K2p 16.1) channel is responsible for modulating glucose stimulated insulin secretion that relies on Beta-cell CA2+ influx. The channel produces outwardly rectifying, non-inactivating K+ currents, which are enhanced by elevations in extracellular pH. TALK-1 is thus pH-sensitive, with increased activity under alkaline conditions. In addition, it can be activated by singlet oxygen and nitric oxide.
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生物信息学
蛋白别名: 2P domain potassium channel Talk-1; pancreatic potassium channel Talk-1; Potassium channel subfamily K member 16; potassium channel, subfamily K, member 16; potassium channel, two pore domain subfamily K, member 16; TALK-1; TWIK-related alkaline pH-activated K(+) channel 1
基因别名: K2p16.1; KCNK16; TALK-1; TALK1
UniProt ID: (Human) Q96T55
Entrez Gene ID: (Human) 83795
