Invitrogen

UBC13 Recombinant Rabbit Monoclonal Antibody (JG38-68)

Name: UBC13 Recombinant Rabbit Monoclonal Antibody (JG38-68)
Brand: Invitrogen
SKU: MA5-34786

查看其他14个UBC13抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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UBC13 Antibody (MA5-34786) in WB

Western blot analysis of Ube2N in Lane 1: Daudi, Lane 2: SH-SY-5Y, Lane 3: Mouse spleen, Lane 4: Rat spleen . Samples were incubated with Ube2N monoclonal antibody (Product # MA5-34786), at a dilution of 1:1000.

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Immunogen image

Immunogen Image UBC13 Recombinant Rabbit Monoclonal Antibody (JG38-68)

产品信息

MA5-34786

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JG38-68

抗原

Recombinant protein within Human Ube2N aa 1-93

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

AB_2848694

产品详细信息

Positive Control: Daudi, SH-SY-5Y, mouse spleen tissue lysate, rat spleen tissue lysate, human colon tissue, human prostate cancer tissue, mouse testis tissue.

靶标信息

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. (Uniprot)

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: bendless-like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; epididymis secretory protein Li 71; MGC131857; MGC8489; Ubc13; UbcH13; Ubiquitin carrier protein N; ubiquitin conjugating enzyme E2N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N; yeast UBC13 homolog

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基因别名: BLU; HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN; UBC13; UBE2N

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UniProt ID: (Human) P61088

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Entrez Gene ID: (Human) 7334

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功能

ubiquitin-protein transferase activity protein binding ATP binding ubiquitin protein ligase binding ubiquitin binding poly(A) RNA binding ubiquitin protein ligase activity ubiquitin conjugating enzyme activity ubiquitin-protein ligase

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