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Invitrogen
USP9X Polyclonal Antibody
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图: 1 / 8
USP9X Antibody (PA5-23035) in ICC/IF
Immunofluorescence analysis of Probable ubiquitin carboxyl-terminal hydrolase FAF-X was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with USP9X Polyclonal Antibody (Product # PA5-23035) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23035
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Genomic peptide made to an internal region of the human Usp9X protein (within residues 1150-1300).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 0.1% BSA, 30% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The target sequence has 95% sequence homology with rat and 80% sequence homology with zebrafish.
靶标信息
USP9X is an ubiquitin-specific protease involved in the removal and recycling of ubiquitin from proteins degraded in proteasomes. As a deubiquitinating enzyme, USP9x has a critical function in tight junction biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a protein shown to facilitate tight junction formation during a narrow temporal window preceding the establishment of cell polarity. USP9X is also located on the X-chromosome but escapes X-inactivation, and defects in USP9X may cause gonadal degeneration in Turner syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: deubiquitinating enzyme FAF-X; Drosophila fat facets related, X-linked; fat facets homolog; fat facets in mammals; fat facets protein related, X-linked; fat facets protein-related, X-linked; fat facets-like, X-linked; fats facets protein related, X; probable ubiquitin carboxyl-terminal hydrolase FAF-X; similar to Homo sapiens ubiquitin hydrolase encoded by GenBank Accession Number X98296; ubiquitin carboxyl-terminal hydrolase FAM; ubiquitin specific peptidase 9, X chromosome; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X; unknown; unnamed protein product
基因别名: 5730589N07Rik; DFFRX; FAF; FAF-X; Fafl; FAM; hFAM; MRX99; MRXS99F; RGD1560056; XLID99
UniProt ID: (Human) Q93008, (Mouse) P70398
Entrez Gene ID: (Human) 8239, (Rat) 363445, (Mouse) 22284
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
cysteine-type peptidase activity
Lys63-specific deubiquitinase activity
co-SMAD binding
ubiquitinyl hydrolase activity
molecular sequestering activity
K11-linked deubiquitinase activity
Lys48-specific deubiquitinase activity
ubiquitin protein ligase binding
in utero embryonic development
neuron migration
DNA dealkylation involved in DNA repair
transforming growth factor beta receptor signaling pathway
post-embryonic development
cell migration
protein import into peroxisome matrix, receptor recycling
protein deubiquitination
cerebellar cortex structural organization
hippocampus development
BMP signaling pathway
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
monoubiquitinated protein deubiquitination
regulation of circadian rhythm
axon extension
protein stabilization
cilium morphogenesis
cytosolic ciliogenesis
protein K63-linked deubiquitination
cellular response to transforming growth factor beta stimulus
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of postsynapse assembly
positive regulation of TORC2 signaling
neuron projection extension
negative regulation of transcription from RNA polymerase II promoter
female gamete generation
protein localization
protein ubiquitination
positive regulation of protein binding
amyloid fibril formation
protein import into peroxisome matrix
regulation of T cell receptor signaling pathway
negative regulation of cilium assembly
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