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Proteintech
APAF1 Polyclonal Antibody
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产品信息
21710-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
APAF1 Fusion Protein Ag16336 (899-1248 aa encoded by BC136532)
偶联物
形式
Liquid
浓度
0.15 mg/mL
规格
22.5 µg
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TSSDDQTIR LWETKKVCKN SAVMLKQEVD VVFQENEVMV LAVDHIRRLQ LINGRTGQID YLTEAQVSCC CLSPHLQYIA FGDENGAIEI LELVNNRIFQ SRFQHKKTVW HIQFTADEKT LISSSDDAEI QVWNWQLDKC IFLRGHQETV KDFRLLKNSR LLSWSFDGTV KVWNIITGNK EKDFVCHQGT VLSCDISHDA TKFSSTSADK TAKIWSFDLL LPLHELRGHN GCVRCSAFSV DSTLLATGDD NGEIRIWNVS NGELLHLCAP LSEEGAATHG GWVTDLCFSP DGKMLISAGG YIKWWNVVTG ESSQTFYTNG TNLKKIHVSP DFKTYVTVDN LGILYILQTL E (899-1248 aa encoded by BC136532)
靶标信息
APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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