Invitrogen

CGRP Polyclonal Antibody

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Datasheet
Protocols
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Tech Support
CGRP Polyclonal Antibody

Product Details

PA5-114931

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CALCA(Accession P06881), corresponding to amino acid residues G96-G120.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899567

Product Specific Information

Antibody detects endogenous levels of total Calcitonin.

Target Information

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; MGC126648; RAT calcitonin

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Gene Aliases: CA; Cal1; CAL6; Calc; CALC1; CALCA; calcitonin; CGRP; CGRP-1; CGRP-I; CGRP1; CT; Ctn; KC; PCT; RATCAL6

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UniProt ID: (Human) P01258, (Rat) P01257, (Mouse) P70160

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Entrez Gene ID: (Human) 796, (Rat) 24241, (Mouse) 12310

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Function(s)
hormone activity protein binding calcitonin receptor binding identical protein binding receptor binding neuropeptide hormone activity protein complex binding peptide hormone
Process(es)
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate monocyte chemotaxis inflammatory response adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway embryo implantation aging feeding behavior response to heat negative regulation of ossification negative regulation of neurological system process activation of protein kinase activity cellular protein metabolic process positive regulation of adenylate cyclase activity positive regulation of ossification negative regulation of bone resorption negative regulation of transcription, DNA-templated negative regulation of smooth muscle contraction response to pain detection of temperature stimulus involved in sensory perception of pain positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure G-protein coupled receptor internalization protein phosphorylation cellular calcium ion homeostasis leukocyte cell-cell adhesion neuromuscular junction development regulation of heart contraction regulation of blood pressure negative regulation of calcium ion transport into cytosol positive regulation of cAMP biosynthetic process receptor internalization positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration positive regulation of macrophage differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure positive regulation of cell adhesion positive regulation of vasodilation regulation of cytosolic calcium ion concentration sperm capacitation mitophagy in response to mitochondrial depolarization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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