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Invitrogen
CGRP Monoclonal Antibody (4901)
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产品信息
MA1-20209
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4901
抗原
Rat alpha-CGRP peptide. The epitope recognized by the antibody resides within the C-terminal ten amino acids of rat alpha-CGRP.
偶联物
形式
Liquid
浓度
2.1 mg/mL
纯化类型
purified
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: rat alpha-CGRP.
MA1-20209 has been successfully used in ELISA, radioimmune assay, neutralizing, and immunocytochemistry procedures.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; MGC126648; prepro-alpha-calcitonin gene-related peptide; RAT calcitonin
基因别名: Cal1; CAL6; CALC; CALC1; CALCA; calcitonin; CCALCI; CGRP; CGRP-I; CGRP1; CT; KC; PCT; RATCAL6
UniProt ID: (Dog) Q9MYV1, (Human) P01258, (Rat) P01257
Entrez Gene ID: (Dog) 403946, (Human) 796, (Rat) 24241
signal transduction
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
regulation of heart rate
monocyte chemotaxis
inflammatory response
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
embryo implantation
aging
feeding behavior
response to heat
negative regulation of ossification
negative regulation of neurological system process
activation of protein kinase activity
cellular protein metabolic process
positive regulation of adenylate cyclase activity
positive regulation of ossification
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
negative regulation of smooth muscle contraction
response to pain
detection of temperature stimulus involved in sensory perception of pain
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cellular response to tumor necrosis factor
cellular response to nerve growth factor stimulus
endothelial cell proliferation
vasculature development
neurological system process involved in regulation of systemic arterial blood pressure
G-protein coupled receptor internalization
protein phosphorylation
cellular calcium ion homeostasis
leukocyte cell-cell adhesion
neuromuscular junction development
regulation of heart contraction
regulation of blood pressure
negative regulation of calcium ion transport into cytosol
positive regulation of cAMP biosynthetic process
receptor internalization
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-8 production
vasodilation
endothelial cell migration
positive regulation of macrophage differentiation
negative regulation of osteoclast differentiation
negative regulation of blood pressure
positive regulation of cell adhesion
positive regulation of vasodilation
regulation of cytosolic calcium ion concentration
