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Proteintech
DLC1 Polyclonal Antibody
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产品信息
15460-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DLC1 Fusion Protein Ag7732 (1179-1528 aa encoded by BC054511)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KDQRLQAIK AAIMLLPDEN REVLQTLLYF LSDVTAAVKE NQMTPTNLAV CLAPSLFHLN TLKRENSSPR VMQRKQSLGK PDQKDLNENL AATQGLAHMI AECKKLFQVP EEMSRCRNSY TEQELKPLTL EALGHLGNDD SADYQHFLQD CVDGLFKEVK EKFKGWVSYS TSEQAELSYK KVSEGPPLRL WRSVIEVPAV PEEILKRLLK EQHLWDVDLL DSKVIEILDS QTEIYQYVQN SMAPHPARDY VVLRTWRTNL PKGACALLLT SVDHDRAPVV GVRVNVLLSR YLIEPCGPGK SKLTYMCRVD LRGHMPEWYT KSFGHLCAAE VVKIRDSFSN QNTETKDTKS R (1179-1528 aa encoded by BC054511)
靶标信息
This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARHGAP 7; Deleted in liver cancer 1 protein; Deleted in liver cancer 1 protein homolog; deleted in liver cancer 1 variant 2; deleted in liver cancer variant 4; DLC 1; DLC-1; FLJ21120; HP protein; p122 RhoGAP; p122-RhoGAP; rho GTPase activating protein 7; Rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; Rho-type GTPase-activating protein 7; StAR-related lipid; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; STARD 12; StARD12; START domain-containing protein 12; transfer protein 12
基因别名: A730069N07Rik; ARHGAP7; dlc-1; DLC1; HP; KIAA1723; p122-RhoGAP; RhoGAP; STARD12
UniProt ID: (Human) Q96QB1, (Mouse) Q9R0Z9
Entrez Gene ID: (Human) 10395, (Mouse) 50768, (Rat) 58834
neural tube closure
heart morphogenesis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
negative regulation of cell proliferation
regulation of cell shape
hindbrain morphogenesis
actin cytoskeleton organization
negative regulation of cell migration
forebrain development
regulation of actin cytoskeleton organization
negative regulation of Rho protein signal transduction
positive regulation of protein dephosphorylation
positive regulation of GTPase activity
focal adhesion assembly
regulation of small GTPase mediated signal transduction
negative regulation of stress fiber assembly
negative regulation of focal adhesion assembly
positive regulation of execution phase of apoptosis
cytoskeleton organization
activation of phospholipase C activity
regulation of Rho protein signal transduction
Rho protein signal transduction
cellular response to insulin stimulus
