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Invitrogen
DLC1 Polyclonal Antibody
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图: 1 / 5
DLC1 Antibody (PA5-18290) in ICC/IF
Immunocytochemistry analysis of DLC1 using DLC1 Polyclonal Antibody (Product # PA5-18290) in paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-18290
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (SVAIRKRSWEEHC) corresponding to the N-terminus amino acids of DLC1 (aa 2-13).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with mouse and porcine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
靶标信息
This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ARHGAP 7; Deleted in liver cancer 1 protein; Deleted in liver cancer 1 protein homolog; DLC 1; DLC-1; FLJ21120; HP protein; p122 RhoGAP; p122-RhoGAP; Rho GTPase-activating protein 7; Rho-type GTPase-activating protein 7; StAR-related lipid; StAR-related lipid transfer protein 12; STARD 12; StARD12; START domain-containing protein 12; transfer protein 12
基因别名: A730069N07Rik; ARHGAP7; dlc-1; DLC1; HP; KIAA1723; STARD12
UniProt ID: (Mouse) Q9R0Z9
Entrez Gene ID: (Mouse) 50768
neural tube closure
heart morphogenesis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cytoskeleton organization
signal transduction
activation of phospholipase C activity
negative regulation of cell proliferation
regulation of cell shape
hindbrain morphogenesis
actin cytoskeleton organization
negative regulation of cell migration
forebrain development
regulation of actin cytoskeleton organization
regulation of Rho protein signal transduction
negative regulation of Rho protein signal transduction
positive regulation of protein dephosphorylation
positive regulation of GTPase activity
focal adhesion assembly
negative regulation of stress fiber assembly
negative regulation of focal adhesion assembly
positive regulation of execution phase of apoptosis
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