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DOCK8 Polyclonal Antibody
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DOCK8 Antibody (600-401-AW8) in IHC (P)
Immunohistochemistry of Rabbit anti-DOCK8 antibody. Tissue: human spleen tissue. Primary antibody: DOCK8 antibody at 5 µg/mL. Secondary antibody: Peroxidase rabbit secondary antibody at 1:5,000. Localization: DOCK8 is located on the membrane. Staining: DOCK8 as precipitated brown signal.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-401-AW8
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-DOCK8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the C-terminus of human DOCK8.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1200017A24Rik; epididymis luminal protein 205; unnamed protein product
基因别名: 1200017A24Rik; 5830472H07Rik; A130095G14Rik; HEL-205; HIES2; MRD2; ZIR8
UniProt ID: (Human) Q8NF50, (Mouse) Q8C147
Entrez Gene ID: (Human) 81704, (Rat) 499337, (Mouse) 76088
immunological synapse formation
small GTPase mediated signal transduction
regulation of Rho protein signal transduction
dendritic cell migration
positive regulation of GTPase activity
memory T cell proliferation
negative regulation of T cell apoptotic process
positive regulation of establishment of T cell polarity
cellular response to chemokine
positive regulation of T cell migration
regulation of small GTPase mediated signal transduction
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