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Invitrogen
EVI1 Polyclonal Antibody
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EVI1 Antibody (PA5-115561) in IHC (P)
Immunohistochemistry analysis of EVI1 in mouse spleen tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115561) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
产品信息
PA5-115561
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MECOM(Accession Q03112), corresponding to amino acid residues A1013-N1063.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MDS1.
靶标信息
EVI1 (MECOM) is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, cell differentiation, and proliferation. It can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. The EVI1 gene can undergo translocation with the AML1 gene, resulting in overexpression of the EVI1 gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AML1-EVI-1 fusion protein; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein; Ecotropic virus integration site 1 protein homolog; EVI-1; Histone-lysine N-methyltransferase MECOM; MDS1 and EVI1 complex locus protein; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MGC163392; MGC97004; myelodysplasia syndrome 1 homolog; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome 1 protein homolog; Myelodysplasia syndrome-associated protein 1; oncogene EVI1; OTTHUMP00000213163; OTTHUMP00000213164; OTTHUMP00000213165; OTTHUMP00000213187; OTTHUMP00000213192; PR domain 3; zinc finger protein Evi1
基因别名: AML1-EVI-1; D630039M04Rik; Evi-1; EVI1; Jbo; Mds; MDS1; MDS1-EVI1; MECOM; PRDM3; RUSAT2; Znfpr1b1
UniProt ID: (Human) Q03112, (Mouse) P14404
Entrez Gene ID: (Human) 2122, (Mouse) 14013, (Rat) 294924
transcription, DNA-templated
apoptotic process
cell differentiation
histone lysine methylation
negative regulation of programmed cell death
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of JNK cascade
regulation of cell cycle
hematopoietic stem cell proliferation
in utero embryonic development
neutrophil homeostasis
inflammatory response
response to bacterium
post-embryonic development
stem cell population maintenance
forebrain development
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
pericardium development
renal system development
positive regulation of brown fat cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
