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Bioss
GPATCH3 Polyclonal Antibody
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GPATCH3 Antibody (BS-13500R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human hepatocellular carcinoma tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-GPATCH3 Polyclonal Antibody, Unconjugated (bs-13500R) at 1:500 overnight at 4°C, followed by a conj... View More
产品信息
BS-13500R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human GPATCH3, amino acids 331-430.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
GPATCH3 is a protein coding gene involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G patch domain containing 3; G patch domain-containing protein 3
基因别名: D930035B09Rik; GPATC3; GPATCH3; RGD1311216
UniProt ID: (Human) Q96I76, (Mouse) Q8BIY1
Entrez Gene ID: (Human) 63906, (Rat) 362615, (Mouse) 242691
