Invitrogen

KDM1B Recombinant Rabbit Monoclonal Antibody (HL3729)

Name: KDM1B Recombinant Rabbit Monoclonal Antibody (HL3729)
Brand: Invitrogen
SKU: MA566194

查看其他8个KDM1B抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

图: 1 / 2

KDM1B Antibody (MA566194) in WB

Western Blot analysis of KDM1B using Various whole cell extracts (30 µg). Samples were separated by 7.5% SDS-PAGE, and the membrane was blotted with KDM1B Recombinant Monoclonal Antibody (Product # MA566194) diluted at 1:1,000. An HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

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产品信息

MA566194

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:10,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

HL3729

抗原

Synthetic peptide of human LSD2/AOF1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; Flavin-containing amine oxidase domain-containing protein 1; lysine (K)-specific demethylase 1B; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2

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基因别名: 4632428N09Rik; AI482520; AOF1; bA204B7.3; C6orf193; dJ298J15.2; KDM1B; LSD2

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UniProt ID: (Human) Q8NB78, (Mouse) Q8CIG3

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Entrez Gene ID: (Human) 221656, (Mouse) 218214

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功能