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Invitrogen
LRRC8A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-72870
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LRRC8A antibody for a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is within amino acids 60 - 110 of LRRC8A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: leucine rich repeat containing 8 family member A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; protein ebouriffe; swelling protein 1; swelling protein 1 SWELL1; unnamed protein product
基因别名: AGM5; ebo; HsLRRC8A; LRRC8; mKIAA1437; SWELL1
UniProt ID: (Human) Q8IWT6, (Mouse) Q80WG5, (Rat) Q4V8I7
Entrez Gene ID: (Human) 56262, (Mouse) 241296, (Rat) 311846
cellular glucose homeostasis
pre-B cell differentiation
anion transport
cell volume homeostasis
response to osmotic stress
spermatogenesis
taurine transport
aspartate transport
positive regulation of insulin secretion
protein hexamerization
positive regulation of myoblast differentiation
anion transmembrane transport
cyclic-GMP-AMP transmembrane import across plasma membrane
chloride transmembrane transport
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
