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Invitrogen
LRRFIP2 Polyclonal Antibody
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LRRFIP2 Antibody (PA5-78569) in IHC (P)
LRRFIP2 Polyclonal Antibody detects LRRFIP2 protein at cytosol on mouse muscle by immunohistochemical analysis. Sample: Paraffin-embedded mouse muscle. LRRFIP2 Polyclonal Antibody (Product # PA5-78569) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-78569
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human LRRFIP2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted Reactivity: Human (100%), Rat (94%), Xenopus laevis (81%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of beta-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kappa-B during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: leucine rich repeat (in FLII) interacting protein 2; Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2
基因别名: 5133400F20Rik; AI850587; HUFI-2; LRRFIP2
UniProt ID: (Human) Q9Y608, (Mouse) Q91WK0
Entrez Gene ID: (Human) 9209, (Mouse) 71268
