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Abnova
NEUROG3 Monoclonal Antibody (4B2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00050674-M06
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B2
抗原
NEUROG3 (NP_066279, 1 a.a. approximately 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE EGGCRGAPRK LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN *
靶标信息
Neurog 3 protein contains one basic helix-loop-helix (bHLH) domain.It is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Not only does itinitiates endocrine cell differentiation, italso promotes islet cell maturation and maintains islet function. It is reported that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: class A basic helix-loop-helix protein 7; neurogenin3; protein atonal homolog 5; unnamed protein product
基因别名: Atoh5; bHLHa7; Math4B; NGN-3; ngn3
UniProt ID: (Human) Q9Y4Z2
Entrez Gene ID: (Human) 50674
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
protein dimerization activity
E-box binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
nervous system development
central nervous system development
peripheral nervous system development
sensory organ development
spinal cord development
forebrain development
hindbrain development
enteroendocrine cell differentiation
positive regulation of cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transdifferentiation
axon development
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
