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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31)

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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31)

产品信息

75-226

应用
建议稀释比
已发表文章

免疫印迹 (WB)

Assay-dependent
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

N126B/31

抗原

Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

TBS, pH 7.4

内含物

0.065% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

Neuregulin-CRD refers to the cysteine-rich domain (CRD) of neuregulins, a family of signaling proteins involved in various cellular processes, including growth, differentiation, and development. The cysteine-rich domain is critical for the interaction of neuregulins with their receptors, such as the ErbB family of receptor tyrosine kinases, facilitating the activation of downstream signaling pathways. This domain plays a vital role in the proper functioning of neuregulins in the nervous system, heart, and other tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: acetylcholine receptor-inducing activity; ErbB4 ligand; glial growth factor; glial growth factor 2; growth and differentiation factor splice variant; growth factor; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; NRG1; pro-NRG1; sensory and motor neuron derived factor; sensory and motor neuron-derived factor splice variant; splice variant of neuregulin family of growth and differentiation factors; type I; type II membrane protein; unnamed protein product

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基因别名: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297

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Entrez Gene ID: (Human) 3084, (Rat) 112400

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功能
transcription cofactor activity receptor binding cytokine activity integrin binding protein binding growth factor activity zinc ion binding nickel cation binding protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity receptor agonist activity ErbB-2 class receptor binding
参与通路
ventricular trabecula myocardium morphogenesis cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development brain development peripheral nervous system development cell proliferation positive regulation of cell proliferation regulation of cell communication negative regulation of cardiac muscle cell apoptotic process neural crest cell development regulation of signaling cell differentiation positive regulation of cell growth mammary gland development positive regulation of protein complex assembly activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB3 signaling pathway ERBB4 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway wound healing positive regulation of cell adhesion negative regulation of transcription, DNA-templated negative chemotaxis negative regulation of secretion positive regulation of developmental process positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of postsynaptic neurotransmitter receptor internalization positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade cell morphogenesis cardiac conduction system development response to stress synapse assembly heart development muscle organ development neuromuscular junction development female pregnancy memory locomotory behavior glial cell differentiation positive regulation of Schwann cell proliferation positive regulation of gene expression cardiac muscle cell apoptotic process positive regulation of neuron projection development Schwann cell development response to muscle activity cell migration sensory perception of pain glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex myelination in peripheral nervous system response to nutrient levels response to progesterone response to vitamin D multicellular organismal response to stress cellular response to potassium ion negative regulation of protein catabolic process myelination regulation of cell differentiation positive regulation of protein kinase activity positive regulation of JNK cascade positive regulation of Ras protein signal transduction neuron fate commitment positive regulation of axon regeneration oligodendrocyte differentiation cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation detection of temperature stimulus involved in sensory perception of pain positive regulation of protein kinase B signaling positive regulation of calcineurin-NFAT signaling cascade cellular response to mechanical stimulus response to dexamethasone postsynapse to nucleus signaling pathway synaptic membrane adhesion cellular response to serotonin cellular response to ciliary neurotrophic factor cellular response to acetylcholine cellular response to L-glutamate regulation of presynapse assembly positive regulation of membrane permeability cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus positive regulation of neural precursor cell proliferation negative regulation of corticosterone secretion negative regulation of neuron migration
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