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Invitrogen
PSEN2 Polyclonal Antibody
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产品信息
PA1-1753
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-1753 detects presenilin 2 protein (PS2) from human, rat and mouse samples.
PA1-1753 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~66 kDa protein representing PS2
The PA1-1753 immunogen is a mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2.
靶标信息
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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