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Antibodies Inc
Pan-MAGUK Monoclonal Antibody (K28/86), FL490
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产品信息
75-029-FL490
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat,
Xenopus,
Zebrafish
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
K28/86
抗原
Fusion protein amino acids 77-299 of human PSD-95/SAP90 produced recombinantly in E. Coli.
偶联物
激发/发射光谱
491/515 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
Pan-MAGUK refers to the collective group of Membrane-Associated Guanylate Kinase (MAGUK) family proteins, which are scaffolding proteins involved in organizing signaling complexes at cellular membranes. These proteins play critical roles in synaptic signaling, cell adhesion, and maintaining the structure of tight junctions. Dysregulation of MAGUK proteins has been linked to various neurological disorders and cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs large 2; discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs large homolog 2; discs large homolog 3; discs large homolog 4; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; discs, large homolog 2; discs, large homolog 2, chapsyn-110; discs, large homolog 3; discs, large homolog 4; Disks large homolog 1; Disks large homolog 2; Disks large homolog 3; Disks large homolog 4; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; membrane associated guanylate kinase; MAGUK; Neuroendocrine-DLG; post-synaptic density protein 95; Postsynaptic density protein 93; Postsynaptic density protein 95; Postsynaptic density protein PSD-93; presynaptic protein SAP97; protein phosphatase 1, regulatory subunit 58; protein phosphatase 1, regulatory subunit 82; PSD-93; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD-95/SAP90-related protein 1; SAP-102; SAP-90; SAP-97; SAP-97A; SAP102; SAP97A; Synapse-associated protein 102; Synapse-associated protein 90; Synapse-associated protein 97; Synapse-associated protein 97A; synapse-associated protein SAP90; synaptic density protein PSD-93; Tax interaction protein 15; XLMR
基因别名: A330103J02Rik; B130052P05Rik; B230218P12Rik; B330007M19Rik; chapsyn-110; dJ1061C18.1.1; DLG1; DLG2; DLG3; DLG4; DLGH1; Dlgh2; Dlgh3; Dlgh4; E-dlg/SAP97; fa66c08; fa66e02; fd02c12; fu95c12; Gm1197; hdlg; im:7138640; KIAA1232; mKIAA1232; mKIAA4187; MRX; MRX90; NEDLG; PPP1R58; PPP1R82; PSD-93; PSD-95; PSD93; PSD95; SAP-90; SAP-97; SAP-97A; SAP102; SAP90; SAP90A; SAP97; si:ch211-276g21.1; wu:fa66c08; wu:fa66e02; wu:fc34d02; wu:fd02c12; wu:fu95c12; XLMR; zgc:55810
guanylate kinase activity
phosphoprotein phosphatase activity
protein binding
protein C-terminus binding
cytoskeletal protein binding
ligand-gated ion channel activity
potassium channel regulator activity
protein kinase binding
phosphatase binding
mitogen-activated protein kinase kinase binding
protein complex scaffold
ionotropic glutamate receptor binding
ion channel binding
L27 domain binding
cadherin binding involved in cell-cell adhesion
kinase binding
protein phosphatase binding
PDZ domain binding
ubiquitin protein ligase binding
Ras guanyl-nucleotide exchange factor activity
beta-1 adrenergic receptor binding
D1 dopamine receptor binding
P2Y1 nucleotide receptor binding
protein complex binding
acetylcholine receptor binding
neuroligin family protein binding
scaffold protein binding
protein heterodimerization activity
protein domain specific binding
receptor binding
glutamate receptor binding
structural molecule activity
neurexin family protein binding
scaffold/adaptor protein
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
immunological synapse formation
endothelial cell proliferation
lens development in camera-type eye
T cell cytokine production
protein dephosphorylation
actin filament organization
mitotic cell cycle checkpoint
establishment or maintenance of cell polarity
chemical synaptic transmission
nervous system development
positive regulation of cell proliferation
regulation of cell shape
viral process
single organismal cell-cell adhesion
peristalsis
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
astral microtubule organization
membrane raft organization
regulation of myelination
activation of protein kinase activity
ion transmembrane transport
cellular protein complex localization
T cell activation
negative regulation of T cell proliferation
regulation of membrane potential
amyloid precursor protein metabolic process
receptor clustering
positive regulation of potassium ion transport
cortical microtubule organization
establishment or maintenance of epithelial cell apical/basal polarity
negative regulation of mitotic cell cycle
GMP metabolic process
GDP metabolic process
reproductive structure development
embryonic skeletal system morphogenesis
smooth muscle tissue development
negative regulation of epithelial cell proliferation
establishment of centrosome localization
negative regulation of protein kinase B signaling
hard palate development
negative regulation of ERK1 and ERK2 cascade
bicellular tight junction assembly
protein localization to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
receptor localization to synapse
regulation of NIK/NF-kappaB signaling
regulation of sodium ion transmembrane transport
negative regulation of p38MAPK cascade
negative regulation of phosphatase activity
sensory perception of pain
establishment of planar polarity
negative regulation of cell proliferation
MAPK cascade
negative regulation of receptor internalization
protein complex assembly
signal transduction
positive regulation of cytosolic calcium ion concentration
learning
synaptic vesicle maturation
social behavior
protein localization to synapse
locomotory exploration behavior
positive regulation of GTPase activity
establishment of protein localization
regulation of long-term neuronal synaptic plasticity
positive regulation of synaptic transmission
neuromuscular process controlling balance
dendritic spine morphogenesis
vocalization behavior
AMPA glutamate receptor clustering
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
ureteric bud development
cell adhesion
protein localization
regulation of protein localization
nucleotide phosphorylation
tissue morphogenesis
positive regulation of multicellular organism growth
positive regulation of developmental growth
neuronal ion channel clustering
locomotory behavior
response to cocaine
regulation of neuronal synaptic plasticity
embryo development
cell-cell adhesion
neurotransmitter receptor localization to postsynaptic specialization membrane
