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Invitrogen
RAGE Polyclonal Antibody
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产品信息
PA1-84173
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, PKKPPQRLEWKLNTGRTE, corresponding to amino acids 42-59 of human RAGE
偶联物
形式
Liquid
保存条件
4°C or -20°C if preferred
运输条件
Wet ice
RRID
产品详细信息
Predicted to react with bovine, chimpanzee, dog, rabbit and rhesus monkey based on sequence homology.
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is diabetic kidney. In Western blot, this antibody detects a band at ~45 kDa in mouse and rat lung lysates.
靶标信息
The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-β peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-?B activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
