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Proteintech
SIRT6 Polyclonal Antibody
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产品信息
13572-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SIRT6 Fusion Protein Ag4469 (1-328 aa encoded by BC028220)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody raised against full length human SIRT6 antigen.
Immunogen sequence: MSVNYAAGL SPYADKGKCG LPEIFDPPEE LERKVWELAR LVWQSSNVVF HTGAGISTAS GIPDFRGPHG VWTMEERGLA PKFDTTFESA RPTQTHMALV QLERVGLLRF LVSQNVDGLH VRSGFPRDKL AELHGNMFVE ECAKCKTQYV RDTVVGTMGL KATGRLCTVA KARGLRACRN ADLSITLGTS LQIRPSGNLP LATKRRGGRL VIVNLQPTKH DRHADLRIHG YVDEVMTRLM KHLGLEIPAW DGPRVLERAL PPLPRPPTPK LEPKEESPTR INGSIPAGPK QEPCAQHNGS EPASPKRERP TSPAPHRPPK RVKAKAVPS (1-328 aa encoded by BC028220 )
靶标信息
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hSIRT6; mSIRT6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2; SIR2 like 6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
基因别名: 2810449N18Rik; AI043036; SIR2L6; SIRT6
UniProt ID: (Human) Q8N6T7, (Mouse) P59941
Entrez Gene ID: (Human) 51548, (Mouse) 50721, (Rat) 299638
chromatin binding
transcription corepressor activity
NAD+ ADP-ribosyltransferase activity
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD+ binding
histone deacetylase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
protein deacetylase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
metal ion binding
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
post-embryonic cardiac muscle cell growth involved in heart morphogenesis
base-excision repair
protein ADP-ribosylation
negative regulation of cell proliferation
regulation of double-strand break repair via homologous recombination
protein destabilization
response to nutrient levels
glucose homeostasis
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
negative regulation of glucose import
positive regulation of fibroblast proliferation
histone H3-K9 modification
histone H3-K9 deacetylation
positive regulation of stem cell proliferation
histone H3 deacetylation
