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Invitrogen
TNFR1 (Atrosimab Biosimilar) Recombinant Human Monoclonal Antibody
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TNFR1 (Atrosimab Biosimilar) Antibody (MA5-54839) in SDS-PAGE
SDS-PAGE analysis of TNFR1 (Atrosimab Biosimilar). Samples were run under reducing (R) and non-reducing (NR) conditions using TNFR1 (Atrosimab Biosimilar) (Product # MA5-54839) monoclonal antibody. The purity of the protein is greater than 95%.
产品信息
MA5-54839
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant Human CD120a/TNFRSF1A/TNFR1.
偶联物
形式
Liquid
浓度
2.48 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF alpha gene; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; TNFR1 beta; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; unnamed protein product
基因别名: CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; TNFRSF1A
UniProt ID: (Human) P19438
Entrez Gene ID: (Human) 7132
aortic valve development
pulmonary valve development
negative regulation of extracellular matrix constituent secretion
transcription from RNA polymerase II promoter
prostaglandin metabolic process
apoptotic process
defense response
inflammatory response
signal transduction
cell surface receptor signaling pathway
JAK-STAT cascade
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of gene expression
positive regulation of macromolecule biosynthetic process
negative regulation of cardiac muscle hypertrophy
regulation of tumor necrosis factor-mediated signaling pathway
cytokine-mediated signaling pathway
tumor necrosis factor-mediated signaling pathway
positive regulation of cellular amide metabolic process
NIK/NF-kappaB signaling
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of lipid metabolic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of developmental process
regulation of multicellular organismal process
cellular response to mechanical stimulus
protein localization to plasma membrane
apoptotic signaling pathway
positive regulation of execution phase of apoptosis
positive regulation of apoptotic process involved in morphogenesis
regulation of establishment of endothelial barrier
regulation of membrane lipid metabolic process
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