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Proteintech
UACA Polyclonal Antibody
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产品信息
25654-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
UACA Fusion Protein Ag22438 (1075-1416 aa encoded by BC113407)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LSQKYTEVK NVKEKLVEEN AKQTSEILAV QNLLQKQHVP LEQVEALKKS LNGTIENLKE ELKSMQRCYE KEQQTVTKLH QLLENQKNSS VPLAEHLQIK EAFEKEVGII KASLREKEEE SQNKMEEVSK LQSEVQNTKQ ALKKLETREV VDLSKYKATK SDLETQISSL NEKLANLNRK YEEVCEEVLH AKKKEISAKD EKELLHFSIE QEIKDQKERC DKSLTTITEL QRRIQESAKQ IEAKDNKITE LLNDVERLKQ ALNGLSQLTY TSGNPTKRQS QLIDTLQHQV KSLEQQLADA DRQHQEVIAI YRTHLLSAAQ GHMDEDVQEA LLQIIQMRQG LVC (1075-1416 aa encoded by BC113407)
靶标信息
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: nuclear membrane binding protein; nuclear membrane binding protein NUCLING; Nuclear membrane-binding protein; Nucling; uveal autoantigen with coiled coil domains and ankyrin repeats; Uveal autoantigen with coiled-coil domains and ankyrin repeats
基因别名: 2700059D02Rik; KIAA1561; NUCLING; UACA
UniProt ID: (Human) Q9BZF9, (Mouse) Q8CGB3
Entrez Gene ID: (Human) 55075, (Mouse) 72565
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
positive regulation of protein import into nucleus
negative regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of inflammatory response
apoptotic signaling pathway
regulation of NIK/NF-kappaB signaling
biological_process
