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Proteintech
ULK1 Polyclonal Antibody
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产品信息
27352-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ULK1 fusion protein Ag22397
偶联物
形式
Liquid
浓度
0.65 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: SRKDLIGHGA FAVVFKGRHR EKHDLEVAVK CINKKNLAKS QTLLGKEIKI LKELKHENIV ALYDFQEMAN SVYLVMEYCN GGDLADYLHA MRTLSEDTIR LFLQQIAGAM RLLHSKGIIH RDLKPQNILL SNPAGRRANP NSIRVKIADF GFARYLQSNM MAATLCGSPM YMAPEVIMSQ HYDGKADLWS IGTIVYQCLT GKAPFQASSP QDLRLFYEKN KTLVPTIPRE TSAPLRQLLL ALLQRNHKDR MDFDEFFHHP FLDASPSVRK SPPVPVPSYP SSGSGSSSSS SSTSHLASPP SLGEMQQLQK TLASPADTAG FLHSSRDSGG SKDSSCDTDD FVMVPAQFPG DLVAEAPSAK PPPDSLMCSG SSLVASAGLE SHGRTPSPSP PCSSSPSPSG RAGPFSSSRC GASVPIPVPT QVQNYQRIER NLQSPTQFQT PRSSAIRRSG
靶标信息
ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase Unc51.1; ULK 1; UNC 51; Unc-51-like kinase 1
基因别名: ATG1; ATG1A; AU041434; hATG1; KIAA0722; mKIAA0722; ULK1; UNC51; Unc51.1
UniProt ID: (Human) O75385, (Mouse) O70405
Entrez Gene ID: (Human) 8408, (Rat) 360827, (Mouse) 22241
protein serine/threonine kinase activity
protein binding
ATP binding
Rab GTPase binding
protein complex binding
molecular_function
protein kinase activity
protein kinase binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Hsp90 protein binding
non-receptor serine/threonine protein kinase
protein phosphorylation
signal transduction
protein localization
regulation of autophagy
positive regulation of autophagy
macroautophagy
positive regulation of macroautophagy
peptidyl-serine phosphorylation
neuron projection regeneration
neuron projection development
negative regulation of protein complex assembly
cellular response to nutrient levels
response to starvation
protein autophosphorylation
axon extension
autophagosome assembly
Ras protein signal transduction
axonogenesis
cerebellar granule cell differentiation
radial glia guided migration of cerebellar granule cell
receptor internalization
negative regulation of collateral sprouting
regulation of neurotrophin TRK receptor signaling pathway
autophagy
regulation of gene expression
regulation of cell death
phosphorylation
mitophagy in response to mitochondrial depolarization
