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          • Primary Antibodies ›
          • Myc Tag Antibodies

          OriGene

          c-Myc Polyclonal Antibody

          查看其他41个Myc Tag抗体

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          Cite c-Myc Polyclonal Antibody

          Additional Information:
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          c-Myc Polyclonal Antibody

          产品信息

          TA100029

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:10,000-1:50,000
          -
          产品规格

          种属反应

          Human, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide: C-EQKLISEEDL (410-419) conjugated with KLH.
          3D表位/免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          See Label

          纯化类型

          Protein A/G

          保存液

          PBS, pH 7.4, with 40% glycerol

          内含物

          0.05% sodium azide

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          靶标信息

          Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: 46-0603; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; c-myc; c-myc epitope tag; c-myc protein, first expressed; Class E basic helix-loop-helix protein 39; cmyc; Myc protein; Myc proto-oncogene protein; Myc Tag; myc-related translation/localization regulatory factor; myelocytomatosis viral oncogene homolog; ORF 114; ORF 114; putative; ORF 118; Proto-oncogene c-Myc; R950-25; R95025; Transcription factor p64; unnamed protein product; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog

          查看更多 收起

          基因别名: BHLHE39; c-Myc; mMyc; MRTL; MYC; MYCC; RNCMYC

          查看更多 收起

          UniProt ID: (Human) P01106, (Rat) P09416

          查看更多 收起

          Entrez Gene ID: (Human) 4609, (Rat) 24577

          查看更多 收起

          功能
          RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding ubiquitin protein ligase binding identical protein binding macromolecular complex binding protein dimerization activity E-box binding DNA-binding transcription factor binding SCF ubiquitin ligase complex binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding double-stranded DNA binding transcription factor binding protein complex binding sequence-specific DNA binding protein heterodimerization activity repressing transcription factor binding basic helix-loop-helix transcription factor
          参与通路
          G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter MAPK cascade branching involved in ureteric bud morphogenesis B cell apoptotic process NK T cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of B cell apoptotic process chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular iron ion homeostasis cellular response to DNA damage stimulus cell proliferation positive regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage response to radiation response to xenobiotic stimulus regulation of gene expression regulation of cell cycle process positive regulation of gene expression myotube differentiation Wnt signaling pathway rRNA metabolic process protein processing regulation of telomere maintenance positive regulation of telomere maintenance negative regulation of stress-activated MAPK cascade protein-DNA complex disassembly cellular response to UV cellular response to interferon-alpha skeletal muscle cell differentiation middle ear morphogenesis regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process response to alkaloid pigmentation hypermethylation of CpG island fibroblast apoptotic process negative regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation negative regulation of fibroblast proliferation skeletal system morphogenesis positive regulation of epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound chromosome organization negative regulation of cell division positive regulation of transcription initiation from RNA polymerase II promoter negative regulation of transcription initiation from RNA polymerase II promoter ERK1 and ERK2 cascade response to growth factor cellular response to hypoxia cellular response to xenobiotic stimulus positive regulation of metanephric cap mesenchymal cell proliferation positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of somatic stem cell population maintenance positive regulation of acinar cell proliferation acinar cell proliferation positive regulation of apoptotic signaling pathway in utero embryonic development regulation of oxidative phosphorylation glucose metabolic process transcription, DNA-templated DNA-templated transcription, initiation pyruvate transport amino acid transport activation of cysteine-type endopeptidase activity involved in apoptotic process inner mitochondrial membrane organization cell cycle arrest regulation of mitotic cell cycle glycoprotein metabolic process pathogenesis response to wounding flavonoid metabolic process response to gamma radiation negative regulation of gene expression positive regulation of mitochondrial membrane potential transformation of host cell by virus hypothalamus development negative regulation of protein binding response to estradiol cellular response to drug response to drug positive regulation of catalytic activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process canonical Wnt signaling pathway involved in positive regulation of wound healing canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process G0 to G1 transition positive regulation of cell cycle positive regulation of glycolytic process negative regulation of glucose import lactic acid secretion canonical Wnt signaling pathway negative regulation of cell death cellular response to carbohydrate stimulus cellular response to interleukin-1 cellular response to estrogen stimulus cellular response to organic cyclic compound cellular response to hydrostatic pressure fungal-type cell wall polysaccharide metabolic process positive regulation of cellular respiration positive regulation of DNA biosynthetic process positive regulation of response to DNA damage stimulus positive regulation of ATP biosynthetic process
          It has to be done as per old AB suggested Products section.

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