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Optimized for biopharmaceutical excellence
Discover a powerful foundation for biopharmaceutical characterization. For intact protein analysis, peptide mapping, oligonucleotide workflows, and impurity profiling with extended mass range up to m/z 8,000, Thermo Scientific Orbitrap Excedion BioPharma hybrid Mass Spectrometer delivers high-resolution, accurate-mass (HRAM) performance.
To extend analytical capability into more advanced structural and functional characterization, the scalable Orbitrap Excedion MS offers a direct in-lab upgrade path to the Thermo Scientific Orbitrap Excedion Pro BioPharma hybrid mass spectrometer. For deeper insights into monoclonal antibodies, complex biotherapeutics, higher-order structure analysis and HDX-MS workflows, Orbitrap Excedion Pro BioPharma introduces extended mass range up to m/z 12,000, and fast and sensitive optional electron-based fragmentation (ETD and EThcD) to increase sequence coverage and confidently localize post-translational modifications.
Highlights: alternative fragmentation and new capabilities
Fast and sensitive alternative fragmentation
Electron Transfer Dissociation (EASY-ETD) option combined with HCD (Higher-Energy Collisional Dissociation) fragmentation delivers unique EThcD (Electron-Transfer/Higher-Energy Collisional Dissociation) fragmentation data on a hybrid benchtop mass spectrometer.
Enhanced performance for larger molecules
Extended mass range up to m/z 12,000 with application mode “Intact Protein”.
Features of Orbitrap Excedion Pro BioPharma Mass Spectrometer
With the Orbitrap Excedion Pro BioPharma Mass Spectrometer, you don't just meet your goals; you exceed them! Embrace the future of mass spectrometry and unlock new possibilities in your research and development endeavors. Discover the power of innovation and exceed your expectations with the Orbitrap Excedion Pro BioPharma MS.
Orbitrap technology
Ultra-high-field Orbitrap mass analyzer with scan speed up to 70 Hz — Scan speed indicates the speed that the instrument acquires MS2 mass spectra per second.
Extended mass range up to m/z 12,000 (unique to BioPharma Edition) — for characterization of intact proteins under native and denatured conditions.
Thermo Scientific OptaMax Plus Ion Source
Enhanced stability — The new heater and sprayer design significantly enhances heat transfer, ensuring superior electrospray stability across a broad temperature range.
User-friendly design — Experience enhanced ease of use with adjustable and reproducible movement to simplify your workflow.
Versatile flow rate compatibility — Supports a wide range of flow rates from 1 - 2,000 µL/min, providing flexibility for various applications.
Electrodynamic ion funnel (EDIF)
Radio frequency (RF) device, optimized for labile compounds, efficiently captures ions as they leave the High-Capacity Transfer Tube (HCTT). Automatic tuning results in broad ion transmission curves with reduced ion losses and increased sensitivity.
EASY-ETD option
Fast and sensitive alternative fragmentation Electron Transfer Dissociation (ETD) generated from fluoranthene radical anions. The townsend discharge provides extremely stable and robust ionization. The EASY-ETD option is compact and contained entirely within the footprint of the instrument.
Intact Protein mode and fast and sensitive alternative fragmentation
With application mode ‘Intact Protein’ (unique to BioPharma Edition), the pressure regimes inside the Ion-Routing Multipole (low, standard and high) can be selected for best performance with native and denaturing conditions.
ETD and EThcD fragmentation occur in the ion routing multipole followed by detection in the Orbitrap mass analyzer.
The EThcD combination provides b- and y-type and c- and z-type fragment ions in a single Orbitrap spectrum.
Improve sustainability with less maintenance
To reduce carbon footprint and overall maintenance, Orbitrap Excedion Pro Mass Spectrometers come standard with a single rough dry pump instead of two oil pumps.
- 30% less energy consumption
- Reduced noise and heat production
Streamlined instrument control software
Software solutions across all next-generation Thermo Scientific platforms for ease of use through different systems. Get meaningful results faster with edition-specific application templates that are ready to use and built into the method editor.
Resources
Service and support
Unity Lab Services provides world-class service solutions to support your instruments. Our comprehensive service portfolio was designed to meet the needs of your lab.
- Instrument service plans
- On-demand services
- Compliance services
- Preventive maintenance
- Installation
- Education
Managing services for your instrument has never been easier. Services Central is a centralized online platform that enables you and your colleagues to request service, view service request status and service history, check service plan or warranty coverage, access manuals, and more.
Our general purpose product lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.
Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks.
For General Lab Use Only - Not For Diagnostic Procedures.
The Thermo Scientific Orbitrap Exploris and Excedion series mass spectrometers are Orbitrap instruments with an atmospheric pressure ionization (API) source for liquid chromatography (LC) mass spectrometry (MS) high-throughput applications. The instruments are designed to be placed on a bench in the laboratory and maintain mass accuracy across chromatographic peaks, supporting confident identification and quantitation using high-resolution accurate-mass detection.