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Empowering metabolomics, lipidomics, Drug MetID/DMPK, and EFS research with deeper detection and confident identification and quantitation
For confident molecular characterization across discovery and development workflows, Thermo Scientific Orbitrap Excedion Mass Spectrometers deliver sensitive detection, structural elucidation, and robust quantitation of known and unknown compounds in complex biological and environmental matrices.
With extended dynamic range, enhanced sensitivity, and high resolving power, Orbitrap Excedion MS enables decision-grade results across pharma DMPK and metabolite identification (MetID), metabolomics, and lipidomics, as well as environmental and food safety research.
Highlights
Superior acquisition rate and resolution
MS/MS acquisition rates of up to 40 Hz in the Orbitrap mass analyzer with maximum resolution of 240,000 at m/z 200.
Enhanced intra scan dynamic range
Enhanced dynamic range (eDR) mode enables five orders of magnitude intrascan dynamic range under defined conditions.
Lower limits of detection for a wider range of molecules
increased ion flux and gentle transfer of ions for lower limits of detection for a wider range of molecules, the high-sensitivity atmospheric pressure interface combines high-capacity ion transfer tube and electrodynamic ion funnel, optimized for labile compounds and efficient ion transfer.
Features of Orbitrap Excedion Mass Spectrometer
The Orbitrap Excedion MS expands your analytical capabilities with confidence—combining high-resolution, accurate-mass performance, extended dynamic range with eDR, exceptional sensitivity, and fast polarity switching to drive deeper insight across small-molecule and multi-omics research.
Built to evolve with your needs, it offers seamless in-lab upgradeability to the Orbitrap Excedion Pro MS, enabling expanded capabilities for advanced omics and biopharma applications.
Built on Orbitrap technology
Ultra-high-field Orbitrap mass analyzer MS2 up to 40 Hz — Scan speed indicates the speed that the instrument acquires MS2 mass spectra per second.
Enhanced dynamic range (eDR) — Full MS mass range is dissected into two Orbitrap subscans, each performing multiplexed isolation and overall MS1 acquisition of equidistant or customizable m/z sub-ranges with efficient ion delivery to the Orbitrap analyzer. Stitching of two Orbitrap subscans is achieved automatically and fully embedded in the data structure. The number of windows within each Orbitrap subscan can be adjusted according to individual needs.
Thermo Scientific OptaMax Plus Ion Source
Enhanced stability — The new heater and sprayer design significantly enhances heat transfer, ensuring exceptional electrospray stability across a broad temperature range.
User-friendly design — Experience enhanced ease of use with adjustable and reproducible movement to simplify your workflow.
Versatile flow rate compatibility — Supports a wide range of flow rates from 1 - 2,000 m/min, providing flexibility for various applications.
Electrodynamic ion funnel (EDIF)
Optimized for labile compounds — Radio frequency (RF) device optimized for labile compounds efficiently capture ions as they leave the High-Capacity Transfer Tube (HCTT). Automatic tuning results in broad ion transmission curves with reduced ion losses, increasing sensitivity.
Improve sustainability with less maintenance
To reduce carbon footprint and overall maintenance, Orbitrap Excedion series mass spectrometers come standard with a single rough dry pump instead of two oil pumps
- 30% less energy consumption
- Reduced noise and heat production
Streamlined instrument control software
Integrated software across next-generation Thermo Scientific platforms ensures a consistent, intuitive user experience—making it easy to work seamlessly across systems. Built-in, edition-specific application templates within the method editor streamline setup and reduce method development time, helping you generate meaningful results faster.
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Service and support
Unity Lab Services provides service solutions to support your instruments. Our comprehensive service portfolio was designed to meet the needs of your lab.
- Instrument service plans
- On-demand services
- Compliance services
- Preventive maintenance
- Installation
- Education
Managing services for your instrument has never been easier. Services Central is a centralized online platform that enables you and your colleagues to request
service, view service request status and service history, check service plan or warranty coverage, access manuals, and more.
FAQs
Get answers to commonly asked questions about Orbitrap Excedion Pro Mass Spectrometer.
The Orbitrap Excedion Mass Spectrometer is designed for high-resolution, accurate-mass (HRAM) small-molecule research. It is well suited for metabolomics, lipidomics, drug metabolism and pharmacokinetics (DMPK), metabolite identification (MetID), and environmental and food safety research workflows that require confident compound identification and quantitation.
The Orbitrap Excedion Mass Spectrometer provides Orbitrap MS/MS acquisition rates of up to 40 Hz and resolving power of up to 240,000 at m/z 200. This combination supports high-confidence identification, accurate quantitation, and high-throughput HRAM workflows without compromising analytical performance.
Yes. The Orbitrap Excedion Mass Spectrometer is designed for in-lab upgradeability, allowing laboratories to upgrade to the Orbitrap Excedion Pro Mass Spectrometer as research requirements expand into advanced omics and biopharma workflows. This helps laboratories extend the useful life of their instrument without replacing the platform.
The Orbitrap Excedion Mass Spectrometer combines high-resolution, accurate-mass performance, enhanced intra-scan dynamic range (eDR), reduced in-source fragmentation for detection of fragile compounds, and high sensitivity in a single platform. These capabilities help laboratories confidently detect, identify, and quantify compounds across demanding small-molecule research workflows while maintaining analytical throughput.
If your laboratory primarily performs metabolomics, lipidomics, DMPK, MetID, environmental, or food safety research, choose the Orbitrap Excedion Mass Spectrometer.
If your research expands into more advanced proteomics or biopharma applications, the platform can be upgraded in the field to the Orbitrap Excedion Pro Mass Spectrometer for more advanced biopharma, proteomics and multi-omics workflows that require EASY-ETD, Hybrid-DIA, TurboTMT, scan speeds up to 70 Hz, and resolving power up to 480,000 at m/z 200.
Yes. For laboratories using legacy Q Exactive Series instruments, the Orbitrap Excedion Mass Spectrometer provides a modern upgrade path with higher acquisition speed, enhanced sensitivity and dynamic range, and advanced capabilities for confident compound identification and quantitation. It enables laboratories to build on established Orbitrap HRAM workflows while increasing analytical performance and productivity.
The Orbitrap Excedion Mass Spectrometer integrates with Thermo Scientific liquid chromatography systems and supports a broad range of LC flow rates through the OptaMax Plus ion source. This flexibility allows laboratories to configure LC-MS workflows for a wide variety of analytical applications.
The Orbitrap Excedion Mass Spectrometer uses an integrated Thermo Scientific software platform with a consistent user interface for instrument control, data acquisition, and method management. Application-specific templates help simplify setup, improve workflow consistency, and support routine operation across multiple research applications.
Our general purpose product lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.
Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks.
For General Lab Use Only - Not For Diagnostic Procedures.