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End-to-end solution for your MS-based HDX analysis
Eliminate the guesswork when selecting the right configuration for your experiments. Every step of our workflow is optimized to deliver maximum insight and a complete, end-to-end solution, along with comprehensive resources to guide you seamlessly through the entire workflow.
Sample preparation HDX-MS
Trajan CHRONECT HDX workstation offers a fully automated HDX-MS platform at your fingertips
To achieve accurate and reproducible results, it is essential to ensure precise timing, maintain tight temperature control, and handle samples carefully - every time. The CHRONECT HDX Workstation addresses these challenges by automating your entire HDX workflow, providing you with the confidence, flexibility, and speed necessary to gain deeper insights into your proteins more quickly and confidently.
Sample separation for HDX-MS
The Thermo Scientific Vanquish Binary Pump N and F UHPLC Systems deliver high reproducibility and sensitivity, supporting nano, capillary, and microflow experiments in a single, all-in-one platform
For high-sensitivity LC-MS applications, Thermo Scientific Vanquish Neo UHPLC System flawlessly integrates with the industry-leading Thermo Scientific mass spectrometer portfolio and ESI sources.
EASY-Spray source enables “plug-and-spray” ionization by pairing the source with integrated column/emitter assemblies and simplified, low-dead-volume connections
The Thermo Scientific EASY-Spray Source is designed to maintain excellent spray stability for efficient evaporation and ionization, which is key to achieving high sensitivity at low-flow rates. It also helps to have better control of back-exchange rate—an important benefit in HDX-MS. This aligns well with emerging low-flow HDX approaches that report markedly improved sensitivity and reduced sample requirements compared with conventional microflow HDX-MS.
Mass spectrometers for HDX-MS
Orbitrap Ascend Structural Biology Mass Spectrometer for experiments that require ultimate characterization and versatility
Exceptional versatility of analysis to enable the ultimate characterization – from peptide-level mapping to intact and native protein characterization, helping interrogate higher-order structure and biomolecular interactions with high performance and flexibility.
Orbitrap Excedion Pro Mass Spectrometer for high-performance characterization of complex biomolecules, with EASY-ETD for more informative fragmentation for structural interpretation
Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer’s ETD/EThcD capability is especially valuable for HDX-ETD (top-down or hybrid strategies) because it provides complementary fragment ion series that support deeper, more localized structural insight, helping map conformational dynamics with greater confidence while maintaining strong sensitivity for challenging, low-level signals.
Orbitrap Exploris 240 Mass Spectrometer for operational simplicity and reliable, high-quality data across routine, high-throughput applications
Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer integrates well into automated HDX workflows and delivers the sensitivity and speed needed for peptide-level HDX measurement, making it a strong entry-point system that can serve as day-to-day instrument..
Data analysis for HDX-MS
HDExaminer PRO offers high-confidence HDX-MS data analysis for fast epitope mapping
HDExaminer PRO is an HDX-MS software solution within the CHRONECT Studio platform, purpose-built for fast, high-confidence HDX-MS data analysis. It removes manual processing steps that slow you down and introduces objective, reproducible results you can trust for epitope identification and binding-site characterization. HDExaminer PRO turns intricate hydrogen deuterium exchange protocols into an intuitive, guided workflow, helping you move from HDX-MS spectra to structural insight significantly faster.