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End-to-end solution for your native MS structural analysis
Eliminate the guesswork when selecting the right configuration for your experiments. Every step of our workflow is optimized to deliver maximum insight through a complete, end-to-end solution, supported by a comprehensive range of resources and expertise to guide you seamlessly from experimental design to data interpretation.
Protein standards for native MS research
Aquaporin Z Membrane Protein Standard
The Thermo Scientific Pierce Aquaporin Z Membrane Protein Standard is a highly validated, high-purity standard. It was designed to support native mass spectrometry method development, system performance verification, parameter optimization, and troubleshooting without consuming valuable membrane protein samples.
VitroEase Apoferritin Standard
The Thermo Scientific VitroEase Apoferritin Standard is a highly validated, high-purity protein standard designed for cryo-EM single particle analysis. It was designed to support grid preparation optimization, performance benchmarking, and quality control for users of all experience levels.
Pierce Intact Protein Standards
The Thermo Scientific Pierce Intact Protein Standard Mix is a high quality mixture of recombinant proteins for use as a quality control standard for LC and LC-MS method development, and intact protein mass measurements.
Sample separation for native MS research
Flexible LC for Native MS
Thermo Scientific Vanquish Flex UHPLC System delivers the flexibility to support a wide range of LC-MS applications without compromising performance. With binary or quaternary solvent blending, they provide high-quality separations, increased productivity, and simplified operation, while offering the precision, detector sensitivity, and ease of use that define the Vanquish UHPLC System.
Size exclusion chromatography columns for native MS
Thermo Scientific MAbPac SEC-1 Size Exclusion Chromatography HPLC Columns provide high-resolution separation of monoclonal antibodies (mAb), including the monomers, aggregates and Fab and Fc fragments resulting from proteolysis. These size-exclusion chromatography columns provide superior performance, even under nondenaturing conditions, and in high- and low-salt mobile phases and volatile eluents.
NativePac OBE-1 SEC column for online sample preparation
Thermo Scientific NativePac OBE-1 SEC columns enable rapid online buffer exchange for native MS, simplifying sample preparation while preserving protein structure and non-covalent interactions. Designed for protein molecular weight and structural screening, these columns efficiently replace non-volatile salts with MS-compatible volatile buffers, reducing analysis time, minimizing buffer consumption, and improving sensitivity for native MS workflows.
Mass spectrometers for native MS research
Q Exactive UHMR Mass Spectrometer for native MS of large biomolecules
The Thermo Scientific Q Exactive UHMR Hybrid Quadrupole Orbitrap Mass Spectrometer is designed for native MS, intact protein analysis, and top-down proteomics of large biomolecules. Combining ultra-high mass range (UHMR) performance with high-resolution accurate-mass (HRAM) detection, it enables confident characterization of protein complexes, viral particles, and other high-mass biomolecular assemblies. Optional Thermo Scientific Direct Mass Technology mode adds charge detection capabilities for improved analysis of complex and heterogeneous samples.
Comprehensive structural biology workflows with Orbitrap Tribrid Apex Structural Biology Mass Spectrometer
Thermo Scientific Orbitrap Tribrid Apex Structural Biology Mass Spectrometer delivers the flexibility needed for a wide range of structural biology applications. It supports native MS, protein crosslinking, hydrogen-deuterium exchange mass spectrometry (HDX-MS), ligand binding, and top-down protein characterization. Its versatile workflow capabilities enable comprehensive analysis of protein structure, interactions, and dynamics on a single platform.
Expanded Capabilities for Structural Biology with Orbitrap Ascend Structural Biology Mass Spectrometer
With an expanded m/z range and multiple fragmentation techniques, the Thermo Scientific Orbitrap Ascend Structural Biology Tribrid Mass Spectrometer supports advanced structural biology workflows. Designed for native MS, top-down proteomics, and higher-order structure analysis, it enables confident characterization of complex biomolecules. Fragmentation options including ETD, EThcD, UVPD, and Proton-Transfer Charge Reduction (PTCR) provide enhanced sequence coverage and confident PTM localization.
Scalable BioPharma structural analysis with Orbitrap Excedion Pro BioPharma Mass Spectrometer
Thermo Scientific Orbitrap Excedion Pro BioPharma Hybrid Mass Spectrometer delivers advanced structural and functional characterization of biotherapeutics. Designed for monoclonal antibodies, complex biologics, higher-order structure analysis, and HDX-MS workflows, it features an extended mass range up to m/z 12,000 and optional electron-based fragmentation (ETD and EThcD) for enhanced sequence coverage and confident localization of PTMs.
Data analysis for native MS
ProsightNative
Unveil the full composition and stoichiometry of a protein complex using ProSight Native’s unique workflow to analyze each level of a complex-down mass spectrometry experiment:
- Intact complex mass analysis
- Subunit mass analysis
- Subunit fragmentation analysis
Proteoform Studio
Proteoform Studio supports both conventional and Direct Mass Technology top-down workflows, giving laboratories flexibility across a wide range of protein characterization applications.
- Intact protein and proteoform characterization
- Top-down fragmentation analysis
- PTM identification and localization
- Complex and heterogeneous protein analysis
With straightforward workflows and intuitive visualization tools, Proteoform Studio helps simplify sophisticated mass spectrometry experiments without sacrificing analytical depth
STORIboard
An easy-to-use interface for processing, visualizing, and analyzing mass spectrometry data collected from Direct Mass Technology mode. Together, Direct Mass Technology mode and STORIboard can reveal the story of even the most complex samples, including viruses, biotherapeutics, and next-generation drug platforms.
Complex biopharmaceutical characterization with Biopharma Finder Software
Thermo Scientific BioPharma Finder software processes subunit, intact, and native MS data with increased throughput, ease, flexibility, and confidence.