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Spatial Proteomics Instruments and Tools

Analytical tools to support spatial proteomics

Discover complete LC-MS/MS solutions for spatial proteomics. With advanced liquid chromatography systems, ion mobility technologies, high-performance Thermo Scientific Orbitrap mass spectrometers, and integrated data analysis software, our portfolio provides the sensitivity, accuracy, and reproducibility needed to uncover unbiased proteomic patterns across tissue.

Separations optimized for spatial proteomics

Vanquish Neo UHPLC System

Supporting high-sensitivity LC-MS workflows essential for spatial proteomics, Thermo Scientific Vanquish Neo UHPLC System provides robust, low-flow separations with minimal carryover.

µPAC Neo Plus 50 cm HPLC Column for experiments that require highly reproducible separations

The Thermo Scientific µPAC Neo Plus 50 cm HPLC Column delivers sharp, reproducible separations for maximum spatial proteomics coverage from both low- and high-area tissue regions of interest.

OptiSpray Ion Source for robust and reproducible nano-and capillary-flow LC-MS in spatial proteomics

The Thermo Scientific OptiSpray Ion Source enables high-sensitivity, reproducible data acquisition for spatial proteomics with automated spray optimization and simplified column installation and handling.

FAIMS Pro Duo Interface - For experiments that require extended dynamic range

Experience enhanced selectivity and sensitivity for low-input spatial proteomics by reducing background and enriching target ions, with the Thermo Scientific FAIMS Pro Duo Interface.

Mass spectrometers for discovery spatial proteomics

Thermo Fisher Scientific is a partner in the life sciences, providing innovative spatial proteomics solutions to address the challenges of biological research. Our portfolio of Orbitrap mass spectrometers delivers the sensitivity, resolution, and throughput required for spatial proteomics.

Mass spectrometers for discovery spatial proteomics

Orbitrap Astral Mass Spectrometer series - For experiments that require exceptional protein depth and acquisition speed

For deep, quantitative protein profiling for spatial proteomics with sensitivity and speed across sub-picogram to microgram inputs, discover the Thermo Scientific Orbitrap Astral Mass Spectrometer series.

Orbitrap Ascend MultiOmics Mass Spectrometer - For experiments that require ultimate characterization and versatility

Experience flexible fragmentation and versatile acquisition strategies for spatial proteomics, including detailed PTM and crosslinked peptide analysis, with the Thermo Scientific Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer.

Orbitrap Excedion Pro Mass Spectrometer for robust spatial proteomics

For deep protein profiling across varied tissue regions in spatial proteomics, the Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer delivers exceptional sensitivity, dynamic range, and reproducibility.

Mass spectrometers for targeted spatial proteomics

Stellar Mass Spectrometer for experiments that require targeted biological interpretation

For spatial proteomics, supporting robust biomarker verification across defined tissue regions, even at low analyst abundance, the Thermo Scientific Stellar Mass Spectrometer enables fast, high-sensitivity targeted quantitation.

Data analysis for discovery spatial proteomics

Proteome Discoverer Software for experiments that require clear biological interpretation

Thermo Scientific Proteome Discoverer Software streamlines spatial proteomics data analysis with flexible workflows that transform complex spectra into confident, biologically meaningful results.

For Research Use Only. Not for use in diagnostic procedures.

General Laboratory Equipment – Not For Diagnostic Procedures. © 2026 Thermo Fisher Scientific Inc. All rights reserved. Thermo Scientific™ products are designated as General Laboratory Equipment and are not intended for use in diagnostic procedures or for in vitro diagnostic purposes. These products are intended for general laboratory use only and have not been tested or validated for diagnostic applications; use for such purposes may result in inaccurate results and may pose health and safety risks. They are designed for research, academic, and industrial applications and for general-purpose analytical use, including high-resolution and accurate-mass measurements, without reference to specific clinical conditions, analytes, or diagnostic decisions.

The Thermo Scientific Orbitrap Exploris and Excedion series mass spectrometers are Orbitrap instruments with an atmospheric pressure ionization (API) source for liquid chromatography (LC) mass spectrometry (MS) high-throughput applications. The instruments are designed to be placed on a bench in the laboratory and maintain mass accuracy across chromatographic peaks, supporting confident identification and quantitation using high-resolution accurate-mass detection.